Cargando…

Pathological and microbiological impact of a gentamicin-loaded biocomposite following limited or extensive debridement in a porcine model of osteomyelitis

AIMS: CERAMENT|G is an absorbable gentamicin-loaded biocomposite used as an on-site vehicle of antimicrobials for the treatment of chronic osteomyelitis. The purpose of the present study was to investigate the sole effect of CERAMENT|G, i.e. without additional systemic antimicrobial therapy, in rela...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blirup-Plum, Sophie A., Bjarnsholt, Thomas, Jensen, Henrik E., Kragh, Kasper N., Aalbæk, Bent, Gottlieb, Hans, Bue, Mats, Jensen, Louise K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The British Editorial Society of Bone and Joint Surgery 2020
Materias:	Infection
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393185/ https://www.ncbi.nlm.nih.gov/pubmed/32793334 http://dx.doi.org/10.1302/2046-3758.97.BJR-2020-0007.R1

Ejemplares similares

Early implant‐associated osteomyelitis results in a peri‐implanted bacterial reservoir
por: Jensen, Louise Kruse, et al.
Publicado: (2016)

Single-dose pharmacokinetics of meropenem in porcine cancellous bone determined by microdialysis: An animal study
por: Hanberg, Pelle, et al.
Publicado: (2019)

A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study
por: Johansen, Louise Kruse, et al.
Publicado: (2011)

Surgical Treatment of Diabetic Foot Ulcers Complicated by Osteomyelitis with Gentamicin-Loaded Calcium Sulphate-Hydroxyapatite Biocomposite
por: Hutting, Kor H., et al.
Publicado: (2021)

Virological and Histopathological Findings in Boars Naturally Infected With Porcine Reproductive and Respiratory Syndrome Virus Type 1
por: Pedersen, Kasper, et al.
Publicado: (2022)

Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis
por: Dvorzhinskiy, Aleksey, et al.
Publicado: (2021)

An observational field study of porcine post-weaning diarrhea: clinical and microbiological findings, and fecal pH-measurements as a potential diagnostic tool
por: Eriksen, Esben Østergaard, et al.
Publicado: (2023)

Whole-Genome Sequence of Staphylococcus aureus S54F9 Isolated from a Chronic Disseminated Porcine Lung Abscess and Used in Human Infection Models
por: Aalbæk, Bent, et al.
Publicado: (2015)

Bacterial biofilms predominate in both acute and chronic human lung infections
por: Kolpen, Mette, et al.
Publicado: (2022)

Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem – evaluated by microdialysis in a porcine model: should patients with open fractures have higher doses of antibiotics?
por: Vittrup, Sofus Ørbæk, et al.
Publicado: (2022)

Synthesis of the cyanobacterial halometabolite Chlorosphaerolactylate B and demonstration of its antimicrobial effect in vitro and in vivo
por: Jensen, Nikoline, et al.
Publicado: (2022)

Combined Staining Techniques for Demonstration of Staphylococcus aureus Biofilm in Routine Histopathology
por: Jensen, Louise Kruse, et al.
Publicado: (2018)

The BACH classification of long bone osteomyelitis
por: Hotchen, Andrew J., et al.
Publicado: (2019)

Rising incidence of Enterococcus species in microbiological specimens from orthopedic patients correlates to increased use of cefuroxime: A study concentrating on tissue samples
por: Siesing, Peter Christian, et al.
Publicado: (2013)

Porcine-Origin Gentamicin-Resistant Enterococcus faecalis in Humans, Denmark
por: Larsen, Jesper, et al.
Publicado: (2010)

Inflammatory proteins in infected bone tissue – An explorative porcine study
por: Bue, Mats, et al.
Publicado: (2020)

Debridement in chronic osteomyelitis with benign osteopetrosis: A case report
por: Liu, Yu-Ping, et al.
Publicado: (2016)

Intra-articular versus systemic vancomycin for the treatment of periprosthetic joint infection after debridement and spacer implantation in a rat model
por: Wei, Jian, et al.
Publicado: (2022)

The Consequences of Being in an Infectious Biofilm: Microenvironmental Conditions Governing Antibiotic Tolerance
por: Sønderholm, Majken, et al.
Publicado: (2017)

Meta-analysis of serum procalcitonin diagnostic test accuracy for osteomyelitis and septic arthritis in children
por: Zhang, Hai-Tao, et al.
Publicado: (2023)

Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): Analysis of risk factors and local antibiotic carriers in 91 patients
por: Kuiper, Jesse W P, et al.
Publicado: (2013)

One-Stage Biopsy, Debridement, Reconstruction, and Stabilization of Pyogenic Vertebral Osteomyelitis
por: Menon, Venugopal K., et al.
Publicado: (2014)

Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold
por: Zhou, J., et al.
Publicado: (2018)

Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration
por: Bendtsen, Mathias A. F., et al.
Publicado: (2021)

The origin of extracellular DNA in bacterial biofilm infections in vivo
por: Alhede, Maria, et al.
Publicado: (2020)

Osteomyelitis of the jaw treated with gentamicin slow releasing beads – a Case report
por: Filipov, Iulian, et al.
Publicado: (2014)

Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis
por: Zhang, Peng, et al.
Publicado: (2019)

Tools for studying growth patterns and chemical dynamics of aggregated Pseudomonas aeruginosa exposed to different electron acceptors in an alginate bead model
por: Sønderholm, Majken, et al.
Publicado: (2018)

Into the well—A close look at the complex structures of a microtiter biofilm and the crystal violet assay
por: Kragh, Kasper Nørskov, et al.
Publicado: (2019)

Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study
por: Kjærgaard, Kasper Aalbæk, et al.
Publicado: (2022)

Radiological and clinical outcomes using induced membrane technique combined with bone marrow concentrate in the treatment of chronic osteomyelitis of immature patients
por: Shen, Jie, et al.
Publicado: (2020)

Incidence and risk factors of recurrence in limb osteomyelitis patients after antibiotic‐loaded cement spacer for definitive bone defect treatment
por: Wu, Hongri, et al.
Publicado: (2023)

Microbiology of Vertebral Osteomyelitis and Implications on Empiric Therapy
por: Clark, Abbye, et al.
Publicado: (2017)

Septic arthritis and osteomyelitis of the pubic symphysis – a retrospective study of 26 patients
por: Hansen, Rehne Lessmann, et al.
Publicado: (2022)

A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis
por: Su, Wen-Yu, et al.
Publicado: (2013)

Preclinical Testing of Radiopharmaceuticals for the Detection and Characterization of Osteomyelitis: Experiences from a Porcine Model
por: Alstrup, Aage Kristian Olsen, et al.
Publicado: (2021)

Antibiotherapy with and without bone debridement in diabetic foot osteomyelitis: A retrospective cohort study
por: Ulcay, Asim, et al.
Publicado: (2014)

Surgical Ulcer Debridement in a Patient With Spina Bifida Complicated by Osteomyelitis, Obesity, and Diabetes
por: Bruzzese, Gabriella L, et al.
Publicado: (2023)

Chronic Diffuse Sclerosing Osteomyelitis of the Mandible
por: Antao, Candice Jacinta, et al.
Publicado: (2019)

Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis
por: Raskov, Hans, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uc6u3adqrdempnui297mc05dr1