Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells

The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central warning signal to induce aversion toward noxious or harmful substances....

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Detalles Bibliográficos
Autores principales: Salvestrini, Valentina, Ciciarello, Marilena, Pensato, Valentina, Simonetti, Giorgia, Laginestra, Maria Antonella, Bruno, Samantha, Pazzaglia, Martina, De Marchi, Elena, Forte, Dorian, Orecchioni, Stefania, Martinelli, Giovanni, Bertolini, Francesco, Méndez-Ferrer, Simon, Adinolfi, Elena, Di Virgilio, Francesco, Cavo, Michele, Curti, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393209/
https://www.ncbi.nlm.nih.gov/pubmed/32793492
http://dx.doi.org/10.3389/fonc.2020.01225

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