Cargando…
Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease
The societal burden of Alzheimer’s disease (AD) is staggering, with current estimates suggesting that 50 million people world-wide have AD. Identification of new therapeutic targets is a critical barrier to the development of disease-modifying therapies. A large body of data implicates vascular path...
Autores principales: | Iannucci, Jaclyn, Renehan, William, Grammas, Paula |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393221/ https://www.ncbi.nlm.nih.gov/pubmed/32792902 http://dx.doi.org/10.3389/fnins.2020.00762 |
Ejemplares similares
-
Thrombin, a Key Driver of Pathological Inflammation in the Brain
por: Iannucci, Jaclyn, et al.
Publicado: (2023) -
Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
por: Grammas, Paula
Publicado: (2011) -
Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia
por: Tripathy, Debjani, et al.
Publicado: (2013) -
Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface
por: Bardehle, Sophia, et al.
Publicado: (2015) -
Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro
por: Iannucci, Jaclyn, et al.
Publicado: (2021)