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Network Analysis of Language Disorganization in Patients with Schizophrenia

Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been exam...

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Autores principales: Park, Seon-Cheol, Kim, Kiwon, Jang, Ok-Jin, Yoon, Hyung-Jun, Jang, Seung-Ho, Kim, Sung-Wan, Lee, Bong Ju, Park, Jae Hong, Lee, Kang Uk, Choi, Joonho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393296/
https://www.ncbi.nlm.nih.gov/pubmed/32734737
http://dx.doi.org/10.3349/ymj.2020.61.8.726
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author Park, Seon-Cheol
Kim, Kiwon
Jang, Ok-Jin
Yoon, Hyung-Jun
Jang, Seung-Ho
Kim, Sung-Wan
Lee, Bong Ju
Park, Jae Hong
Lee, Kang Uk
Choi, Joonho
author_facet Park, Seon-Cheol
Kim, Kiwon
Jang, Ok-Jin
Yoon, Hyung-Jun
Jang, Seung-Ho
Kim, Sung-Wan
Lee, Bong Ju
Park, Jae Hong
Lee, Kang Uk
Choi, Joonho
author_sort Park, Seon-Cheol
collection PubMed
description Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results indicated that disclosure failure, excess syntactic constraints, abnormal prosody, and aprosodic speech rank among the top five central domains within the network structure. We deemed that disclosure failure and prosody problems are the most important symptoms of language disorder in schizophrenia. Thus, reduced top-down processing of linguistic information may be a core neurobiological underpinning of language disorganization in schizophrenia. Further studies controlling for the potential effects of confounding factors (i.e., duration of illness) on network analyses of language disorder and formal thought disorder are warranted in patients with schizophrenia.
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spelling pubmed-73932962020-08-10 Network Analysis of Language Disorganization in Patients with Schizophrenia Park, Seon-Cheol Kim, Kiwon Jang, Ok-Jin Yoon, Hyung-Jun Jang, Seung-Ho Kim, Sung-Wan Lee, Bong Ju Park, Jae Hong Lee, Kang Uk Choi, Joonho Yonsei Med J Brief Communication Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results indicated that disclosure failure, excess syntactic constraints, abnormal prosody, and aprosodic speech rank among the top five central domains within the network structure. We deemed that disclosure failure and prosody problems are the most important symptoms of language disorder in schizophrenia. Thus, reduced top-down processing of linguistic information may be a core neurobiological underpinning of language disorganization in schizophrenia. Further studies controlling for the potential effects of confounding factors (i.e., duration of illness) on network analyses of language disorder and formal thought disorder are warranted in patients with schizophrenia. Yonsei University College of Medicine 2020-08-01 2020-07-28 /pmc/articles/PMC7393296/ /pubmed/32734737 http://dx.doi.org/10.3349/ymj.2020.61.8.726 Text en © Copyright: Yonsei University College of Medicine 2020 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Park, Seon-Cheol
Kim, Kiwon
Jang, Ok-Jin
Yoon, Hyung-Jun
Jang, Seung-Ho
Kim, Sung-Wan
Lee, Bong Ju
Park, Jae Hong
Lee, Kang Uk
Choi, Joonho
Network Analysis of Language Disorganization in Patients with Schizophrenia
title Network Analysis of Language Disorganization in Patients with Schizophrenia
title_full Network Analysis of Language Disorganization in Patients with Schizophrenia
title_fullStr Network Analysis of Language Disorganization in Patients with Schizophrenia
title_full_unstemmed Network Analysis of Language Disorganization in Patients with Schizophrenia
title_short Network Analysis of Language Disorganization in Patients with Schizophrenia
title_sort network analysis of language disorganization in patients with schizophrenia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393296/
https://www.ncbi.nlm.nih.gov/pubmed/32734737
http://dx.doi.org/10.3349/ymj.2020.61.8.726
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