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Network Analysis of Language Disorganization in Patients with Schizophrenia
Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been exam...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393296/ https://www.ncbi.nlm.nih.gov/pubmed/32734737 http://dx.doi.org/10.3349/ymj.2020.61.8.726 |
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author | Park, Seon-Cheol Kim, Kiwon Jang, Ok-Jin Yoon, Hyung-Jun Jang, Seung-Ho Kim, Sung-Wan Lee, Bong Ju Park, Jae Hong Lee, Kang Uk Choi, Joonho |
author_facet | Park, Seon-Cheol Kim, Kiwon Jang, Ok-Jin Yoon, Hyung-Jun Jang, Seung-Ho Kim, Sung-Wan Lee, Bong Ju Park, Jae Hong Lee, Kang Uk Choi, Joonho |
author_sort | Park, Seon-Cheol |
collection | PubMed |
description | Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results indicated that disclosure failure, excess syntactic constraints, abnormal prosody, and aprosodic speech rank among the top five central domains within the network structure. We deemed that disclosure failure and prosody problems are the most important symptoms of language disorder in schizophrenia. Thus, reduced top-down processing of linguistic information may be a core neurobiological underpinning of language disorganization in schizophrenia. Further studies controlling for the potential effects of confounding factors (i.e., duration of illness) on network analyses of language disorder and formal thought disorder are warranted in patients with schizophrenia. |
format | Online Article Text |
id | pubmed-7393296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-73932962020-08-10 Network Analysis of Language Disorganization in Patients with Schizophrenia Park, Seon-Cheol Kim, Kiwon Jang, Ok-Jin Yoon, Hyung-Jun Jang, Seung-Ho Kim, Sung-Wan Lee, Bong Ju Park, Jae Hong Lee, Kang Uk Choi, Joonho Yonsei Med J Brief Communication Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results indicated that disclosure failure, excess syntactic constraints, abnormal prosody, and aprosodic speech rank among the top five central domains within the network structure. We deemed that disclosure failure and prosody problems are the most important symptoms of language disorder in schizophrenia. Thus, reduced top-down processing of linguistic information may be a core neurobiological underpinning of language disorganization in schizophrenia. Further studies controlling for the potential effects of confounding factors (i.e., duration of illness) on network analyses of language disorder and formal thought disorder are warranted in patients with schizophrenia. Yonsei University College of Medicine 2020-08-01 2020-07-28 /pmc/articles/PMC7393296/ /pubmed/32734737 http://dx.doi.org/10.3349/ymj.2020.61.8.726 Text en © Copyright: Yonsei University College of Medicine 2020 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Park, Seon-Cheol Kim, Kiwon Jang, Ok-Jin Yoon, Hyung-Jun Jang, Seung-Ho Kim, Sung-Wan Lee, Bong Ju Park, Jae Hong Lee, Kang Uk Choi, Joonho Network Analysis of Language Disorganization in Patients with Schizophrenia |
title | Network Analysis of Language Disorganization in Patients with Schizophrenia |
title_full | Network Analysis of Language Disorganization in Patients with Schizophrenia |
title_fullStr | Network Analysis of Language Disorganization in Patients with Schizophrenia |
title_full_unstemmed | Network Analysis of Language Disorganization in Patients with Schizophrenia |
title_short | Network Analysis of Language Disorganization in Patients with Schizophrenia |
title_sort | network analysis of language disorganization in patients with schizophrenia |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393296/ https://www.ncbi.nlm.nih.gov/pubmed/32734737 http://dx.doi.org/10.3349/ymj.2020.61.8.726 |
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