miR-137: A Novel Therapeutic Target for Human Glioma

MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yajun, Chen, Riling, Zhou, Xia, Guo, Runmin, Yin, Jingwen, Li, You, Ma, Guoda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393316/
https://www.ncbi.nlm.nih.gov/pubmed/32736290
http://dx.doi.org/10.1016/j.omtn.2020.06.028
_version_ 1783565018669776896
author Wang, Yajun
Chen, Riling
Zhou, Xia
Guo, Runmin
Yin, Jingwen
Li, You
Ma, Guoda
author_facet Wang, Yajun
Chen, Riling
Zhou, Xia
Guo, Runmin
Yin, Jingwen
Li, You
Ma, Guoda
author_sort Wang, Yajun
collection PubMed
description MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.
format Online
Article
Text
id pubmed-7393316
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Society of Gene & Cell Therapy
record_format MEDLINE/PubMed
spelling pubmed-73933162020-08-07 miR-137: A Novel Therapeutic Target for Human Glioma Wang, Yajun Chen, Riling Zhou, Xia Guo, Runmin Yin, Jingwen Li, You Ma, Guoda Mol Ther Nucleic Acids Article MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed. American Society of Gene & Cell Therapy 2020-06-30 /pmc/articles/PMC7393316/ /pubmed/32736290 http://dx.doi.org/10.1016/j.omtn.2020.06.028 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Yajun
Chen, Riling
Zhou, Xia
Guo, Runmin
Yin, Jingwen
Li, You
Ma, Guoda
miR-137: A Novel Therapeutic Target for Human Glioma
title miR-137: A Novel Therapeutic Target for Human Glioma
title_full miR-137: A Novel Therapeutic Target for Human Glioma
title_fullStr miR-137: A Novel Therapeutic Target for Human Glioma
title_full_unstemmed miR-137: A Novel Therapeutic Target for Human Glioma
title_short miR-137: A Novel Therapeutic Target for Human Glioma
title_sort mir-137: a novel therapeutic target for human glioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393316/
https://www.ncbi.nlm.nih.gov/pubmed/32736290
http://dx.doi.org/10.1016/j.omtn.2020.06.028
work_keys_str_mv AT wangyajun mir137anoveltherapeutictargetforhumanglioma
AT chenriling mir137anoveltherapeutictargetforhumanglioma
AT zhouxia mir137anoveltherapeutictargetforhumanglioma
AT guorunmin mir137anoveltherapeutictargetforhumanglioma
AT yinjingwen mir137anoveltherapeutictargetforhumanglioma
AT liyou mir137anoveltherapeutictargetforhumanglioma
AT maguoda mir137anoveltherapeutictargetforhumanglioma

Ejemplares similares