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Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis

Hotspot p53 mutant proteins often gain novel functions in promoting tumor metastases. However, the molecular mechanisms by which mutant p53 exerts gain-of-function in cancer are not totally understood. In this study, we demonstrate that hotspot mutant p53, p53-R273H, promotes cell scattering growth...

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Detalles Bibliográficos
Autores principales:	Sun, Shengnan, Chen, Hu, Sun, Lijuan, Wang, Miao, Wu, Xianqiang, Xiao, Zhi-Xiong Jim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393383/ https://www.ncbi.nlm.nih.gov/pubmed/32733026 http://dx.doi.org/10.1038/s41419-020-02814-1

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