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Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

OBJECTIVE: Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was designed to address this question. METHOD...

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Detalles Bibliográficos
Autores principales:	Riopel, Matthew, Moon, Jae-Su, Bandyopadhyay, Gautam K., You, Seohee, Lam, Kevin, Liu, Xiao, Kisseleva, Tatiana, Brenner, David, Lee, Yun Sok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393408/ https://www.ncbi.nlm.nih.gov/pubmed/32534258 http://dx.doi.org/10.1016/j.molmet.2020.101039

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