Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation,...

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Detalles Bibliográficos
Autores principales: Toor, Iqbal S., Rückerl, Dominik, Mair, Iris, Ainsworth, Rob, Meloni, Marco, Spiroski, Ana-Mishel, Benezech, Cecile, Felton, Jennifer M., Thomson, Adrian, Caporali, Andrea, Keeble, Thomas, Tang, Kare H., Rossi, Adriano G., Newby, David E., Allen, Judith E., Gray, Gillian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393409/
https://www.ncbi.nlm.nih.gov/pubmed/32760855
http://dx.doi.org/10.1016/j.jacbts.2020.05.005
Descripción
Sumario:In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

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