Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation,...

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Autores principales: Toor, Iqbal S., Rückerl, Dominik, Mair, Iris, Ainsworth, Rob, Meloni, Marco, Spiroski, Ana-Mishel, Benezech, Cecile, Felton, Jennifer M., Thomson, Adrian, Caporali, Andrea, Keeble, Thomas, Tang, Kare H., Rossi, Adriano G., Newby, David E., Allen, Judith E., Gray, Gillian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393409/
https://www.ncbi.nlm.nih.gov/pubmed/32760855
http://dx.doi.org/10.1016/j.jacbts.2020.05.005
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author Toor, Iqbal S.
Rückerl, Dominik
Mair, Iris
Ainsworth, Rob
Meloni, Marco
Spiroski, Ana-Mishel
Benezech, Cecile
Felton, Jennifer M.
Thomson, Adrian
Caporali, Andrea
Keeble, Thomas
Tang, Kare H.
Rossi, Adriano G.
Newby, David E.
Allen, Judith E.
Gray, Gillian A.
author_facet Toor, Iqbal S.
Rückerl, Dominik
Mair, Iris
Ainsworth, Rob
Meloni, Marco
Spiroski, Ana-Mishel
Benezech, Cecile
Felton, Jennifer M.
Thomson, Adrian
Caporali, Andrea
Keeble, Thomas
Tang, Kare H.
Rossi, Adriano G.
Newby, David E.
Allen, Judith E.
Gray, Gillian A.
author_sort Toor, Iqbal S.
collection PubMed
description In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.
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spelling pubmed-73934092020-08-04 Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction Toor, Iqbal S. Rückerl, Dominik Mair, Iris Ainsworth, Rob Meloni, Marco Spiroski, Ana-Mishel Benezech, Cecile Felton, Jennifer M. Thomson, Adrian Caporali, Andrea Keeble, Thomas Tang, Kare H. Rossi, Adriano G. Newby, David E. Allen, Judith E. Gray, Gillian A. JACC Basic Transl Sci CLINICAL RESEARCH In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy. Elsevier 2020-07-08 /pmc/articles/PMC7393409/ /pubmed/32760855 http://dx.doi.org/10.1016/j.jacbts.2020.05.005 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle CLINICAL RESEARCH
Toor, Iqbal S.
Rückerl, Dominik
Mair, Iris
Ainsworth, Rob
Meloni, Marco
Spiroski, Ana-Mishel
Benezech, Cecile
Felton, Jennifer M.
Thomson, Adrian
Caporali, Andrea
Keeble, Thomas
Tang, Kare H.
Rossi, Adriano G.
Newby, David E.
Allen, Judith E.
Gray, Gillian A.
Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title_full Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title_fullStr Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title_full_unstemmed Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title_short Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
title_sort eosinophil deficiency promotes aberrant repair and adverse remodeling following acute myocardial infarction
topic CLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393409/
https://www.ncbi.nlm.nih.gov/pubmed/32760855
http://dx.doi.org/10.1016/j.jacbts.2020.05.005
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