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Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country
Globally, drug-resistant epilepsy affects one third of people living with epilepsy. With limitations in treatment options for refractory epilepsy in resource-limited regions, ketogenic diet therapy is an important option to consider. Utilizing the 2015 International League Against Epilepsy recommend...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393450/ https://www.ncbi.nlm.nih.gov/pubmed/32760907 http://dx.doi.org/10.1016/j.ebr.2020.100380 |
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author | Nkole, Kafula Lisa Kawatu, Nfwama Patel, Archana A. Kanyinji, Chimbizyani Njobvu, Theresa Chipeta, James Musuku, John Ciccone, Ornella Tarrant, Stacey Bergin, Ann Marie |
author_facet | Nkole, Kafula Lisa Kawatu, Nfwama Patel, Archana A. Kanyinji, Chimbizyani Njobvu, Theresa Chipeta, James Musuku, John Ciccone, Ornella Tarrant, Stacey Bergin, Ann Marie |
author_sort | Nkole, Kafula Lisa |
collection | PubMed |
description | Globally, drug-resistant epilepsy affects one third of people living with epilepsy. With limitations in treatment options for refractory epilepsy in resource-limited regions, ketogenic diet therapy is an important option to consider. Utilizing the 2015 International League Against Epilepsy recommended minimum requirements for ketogenic diet therapy, three male children with refractory epilepsy, aged 2.5, 6.5 and 10 years, were initiated on the classical ketogenic diet using locally available food in August 2017 at University Teaching Hospitals-Children's Hospital in Lusaka, Zambia, through partnership with the Epilepsy Program at Boston Children's Hospital in the United States. Following successful initiation in all three children, the diet was discontinued in the 10-year-old due to difficulties complying with the diet. The youngest child demonstrated an over 50% seizure reduction and gained developmental milestones. The third child achieved seizure freedom and showed marked improvement in behaviour. This pilot demonstrates the feasibility of ketogenic diet as an important therapeutic option for refractory epilepsy in Zambia. Given the limitations in treatment choices and medication accessibility, dietary therapy offers an alternative management strategy in our setting. Collaboration with an established ketogenic diet centre contributes to a successful program. |
format | Online Article Text |
id | pubmed-7393450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73934502020-08-04 Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country Nkole, Kafula Lisa Kawatu, Nfwama Patel, Archana A. Kanyinji, Chimbizyani Njobvu, Theresa Chipeta, James Musuku, John Ciccone, Ornella Tarrant, Stacey Bergin, Ann Marie Epilepsy Behav Rep Article Globally, drug-resistant epilepsy affects one third of people living with epilepsy. With limitations in treatment options for refractory epilepsy in resource-limited regions, ketogenic diet therapy is an important option to consider. Utilizing the 2015 International League Against Epilepsy recommended minimum requirements for ketogenic diet therapy, three male children with refractory epilepsy, aged 2.5, 6.5 and 10 years, were initiated on the classical ketogenic diet using locally available food in August 2017 at University Teaching Hospitals-Children's Hospital in Lusaka, Zambia, through partnership with the Epilepsy Program at Boston Children's Hospital in the United States. Following successful initiation in all three children, the diet was discontinued in the 10-year-old due to difficulties complying with the diet. The youngest child demonstrated an over 50% seizure reduction and gained developmental milestones. The third child achieved seizure freedom and showed marked improvement in behaviour. This pilot demonstrates the feasibility of ketogenic diet as an important therapeutic option for refractory epilepsy in Zambia. Given the limitations in treatment choices and medication accessibility, dietary therapy offers an alternative management strategy in our setting. Collaboration with an established ketogenic diet centre contributes to a successful program. Elsevier 2020-07-03 /pmc/articles/PMC7393450/ /pubmed/32760907 http://dx.doi.org/10.1016/j.ebr.2020.100380 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Nkole, Kafula Lisa Kawatu, Nfwama Patel, Archana A. Kanyinji, Chimbizyani Njobvu, Theresa Chipeta, James Musuku, John Ciccone, Ornella Tarrant, Stacey Bergin, Ann Marie Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title | Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title_full | Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title_fullStr | Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title_full_unstemmed | Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title_short | Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country |
title_sort | ketogenic diet in zambia: managing drug-resistant epilepsy in a low and middle income country |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393450/ https://www.ncbi.nlm.nih.gov/pubmed/32760907 http://dx.doi.org/10.1016/j.ebr.2020.100380 |
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