Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor and has the highest mortality rate among cancers and high resistance to radiation and cytotoxic chemotherapy. Although some targeted therapies can partially inhibit oncogenic mutation-driven proliferation of GBM cells, therapies...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Jing, Li, Tan, Subee, Zeng, Er-Ming, Lin, Yingbo, He, Lingfeng, Hu, Zhigang, Liu, Jianping, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393494/
https://www.ncbi.nlm.nih.gov/pubmed/32732911
http://dx.doi.org/10.1038/s41419-020-02812-3

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