Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy defects in TNBC cel...

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Detalles Bibliográficos
Autores principales: Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Huang, Jun-Hao, Sun, Peng, Zhou, Ning-Ning, Chen, Yu-Hong, Mai, Jia, Wang, Yan, Yu, Yan, Zhou, Li-Huan, Li, Xuan, Yang, Dong, Peng, Xiao-Dan, Feng, Gong-Kan, Tang, Jun, Zhu, Xiao-Feng, Deng, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393512/
https://www.ncbi.nlm.nih.gov/pubmed/32732922
http://dx.doi.org/10.1038/s41467-020-17395-y

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