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Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion

BACKGROUND: This study aimed to establish and validate a novel scoring system based on a nomogram for the differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE). METHODS: Patients with PE and confirmed aetiology who underwent diagnostic thoracentesis were includ...

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Autores principales: Wang, Sufei, Tian, Shan, Li, Yuan, Zhan, Na, Guo, Yingyun, Liu, Yu, Xu, Juanjuan, Ma, Yanling, Zhang, Shujing, Song, Siwei, Geng, Wei, Xia, Hui, Ma, Pei, Wang, Xuan, Liao, Tingting, Duan, Yanran, Jin, Yang, Dong, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393523/
https://www.ncbi.nlm.nih.gov/pubmed/32739872
http://dx.doi.org/10.1016/j.ebiom.2020.102924
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author Wang, Sufei
Tian, Shan
Li, Yuan
Zhan, Na
Guo, Yingyun
Liu, Yu
Xu, Juanjuan
Ma, Yanling
Zhang, Shujing
Song, Siwei
Geng, Wei
Xia, Hui
Ma, Pei
Wang, Xuan
Liao, Tingting
Duan, Yanran
Jin, Yang
Dong, Weiguo
author_facet Wang, Sufei
Tian, Shan
Li, Yuan
Zhan, Na
Guo, Yingyun
Liu, Yu
Xu, Juanjuan
Ma, Yanling
Zhang, Shujing
Song, Siwei
Geng, Wei
Xia, Hui
Ma, Pei
Wang, Xuan
Liao, Tingting
Duan, Yanran
Jin, Yang
Dong, Weiguo
author_sort Wang, Sufei
collection PubMed
description BACKGROUND: This study aimed to establish and validate a novel scoring system based on a nomogram for the differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE). METHODS: Patients with PE and confirmed aetiology who underwent diagnostic thoracentesis were included in this study. One retrospective set (N = 1261) was used to develop and internally validate the predictive model. The clinical, radiological and laboratory features were collected and subjected to logistic regression analyses. The primary predictive model was displayed as a nomogram and then modified into a novel scoring system, which was externally validated in an independent set (N = 172). FINDINGS: The novel scoring system was composed of fever (3 points), erythrocyte sedimentation rate (4 points), effusion adenosine deaminase (7 points), serum carcinoembryonic antigen (CEA) (4 points), effusion CEA (10 points) and effusion/serum CEA (8 points). With a cutoff value of 15 points, the area under the curve, specificity and sensitivity for identifying MPE were 0.913, 89.10%, and 82.63%, respectively, in the training set, 0.922, 93.48%, 81.51%, respectively, in the internal validation set and 0.912, 87.61%, 81.36%, respectively, in the external validation set. Moreover, this scoring system was exclusively applied to distinguish lung cancer with PE from tuberculous pleurisy and showed a favourable diagnostic performance in the training and validation sets. INTERPRETATION: This novel scoring system was developed from a retrospective study and externally validated in an independent set based on six easily accessible clinical variables, and it exhibited good diagnostic performance for identifying MPE. FUNDING: NFSC grants (no. 81572942, no. 81800094).
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spelling pubmed-73935232020-08-04 Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion Wang, Sufei Tian, Shan Li, Yuan Zhan, Na Guo, Yingyun Liu, Yu Xu, Juanjuan Ma, Yanling Zhang, Shujing Song, Siwei Geng, Wei Xia, Hui Ma, Pei Wang, Xuan Liao, Tingting Duan, Yanran Jin, Yang Dong, Weiguo EBioMedicine Research paper BACKGROUND: This study aimed to establish and validate a novel scoring system based on a nomogram for the differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE). METHODS: Patients with PE and confirmed aetiology who underwent diagnostic thoracentesis were included in this study. One retrospective set (N = 1261) was used to develop and internally validate the predictive model. The clinical, radiological and laboratory features were collected and subjected to logistic regression analyses. The primary predictive model was displayed as a nomogram and then modified into a novel scoring system, which was externally validated in an independent set (N = 172). FINDINGS: The novel scoring system was composed of fever (3 points), erythrocyte sedimentation rate (4 points), effusion adenosine deaminase (7 points), serum carcinoembryonic antigen (CEA) (4 points), effusion CEA (10 points) and effusion/serum CEA (8 points). With a cutoff value of 15 points, the area under the curve, specificity and sensitivity for identifying MPE were 0.913, 89.10%, and 82.63%, respectively, in the training set, 0.922, 93.48%, 81.51%, respectively, in the internal validation set and 0.912, 87.61%, 81.36%, respectively, in the external validation set. Moreover, this scoring system was exclusively applied to distinguish lung cancer with PE from tuberculous pleurisy and showed a favourable diagnostic performance in the training and validation sets. INTERPRETATION: This novel scoring system was developed from a retrospective study and externally validated in an independent set based on six easily accessible clinical variables, and it exhibited good diagnostic performance for identifying MPE. FUNDING: NFSC grants (no. 81572942, no. 81800094). Elsevier 2020-07-30 /pmc/articles/PMC7393523/ /pubmed/32739872 http://dx.doi.org/10.1016/j.ebiom.2020.102924 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research paper
Wang, Sufei
Tian, Shan
Li, Yuan
Zhan, Na
Guo, Yingyun
Liu, Yu
Xu, Juanjuan
Ma, Yanling
Zhang, Shujing
Song, Siwei
Geng, Wei
Xia, Hui
Ma, Pei
Wang, Xuan
Liao, Tingting
Duan, Yanran
Jin, Yang
Dong, Weiguo
Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title_full Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title_fullStr Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title_full_unstemmed Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title_short Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
title_sort development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion
topic Research paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393523/
https://www.ncbi.nlm.nih.gov/pubmed/32739872
http://dx.doi.org/10.1016/j.ebiom.2020.102924
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