GMM-Demux: sample demultiplexing, multiplet detection, experiment planning, and novel cell-type verification in single cell sequencing

Identifying and removing multiplets are essential to improving the scalability and the reliability of single cell RNA sequencing (scRNA-seq). Multiplets create artificial cell types in the dataset. We propose a Gaussian mixture model-based multiplet identification method, GMM-Demux. GMM-Demux accura...

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Detalles Bibliográficos
Autores principales: Xin, Hongyi, Lian, Qiuyu, Jiang, Yale, Luo, Jiadi, Wang, Xinjun, Erb, Carla, Xu, Zhongli, Zhang, Xiaoyi, Heidrich-O’Hare, Elisa, Yan, Qi, Duerr, Richard H., Chen, Kong, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393741/
https://www.ncbi.nlm.nih.gov/pubmed/32731885
http://dx.doi.org/10.1186/s13059-020-02084-2

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