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Is placental KISS-1 expression associated with first trimester abortion spontaneous?

OBJECTIVE: Several studies have examined biological markers during the first trimester to predict the maintenance of a healthy pregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether first-trimester pregnancy losses were associated with levels of...

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Autores principales: Colak, Eser, Ozcimen, Emel Ebru, Erinanç, Ozgur Hilal, Tohma, Yusuf Aytac, Ceran, Mehmet Ufuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393744/
https://www.ncbi.nlm.nih.gov/pubmed/32689775
http://dx.doi.org/10.5468/ogs.19242
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author Colak, Eser
Ozcimen, Emel Ebru
Erinanç, Ozgur Hilal
Tohma, Yusuf Aytac
Ceran, Mehmet Ufuk
author_facet Colak, Eser
Ozcimen, Emel Ebru
Erinanç, Ozgur Hilal
Tohma, Yusuf Aytac
Ceran, Mehmet Ufuk
author_sort Colak, Eser
collection PubMed
description OBJECTIVE: Several studies have examined biological markers during the first trimester to predict the maintenance of a healthy pregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether first-trimester pregnancy losses were associated with levels of placental KISS-1 expression. METHODS: This prospective case control study was conducted at a tertiary center. The study group included 27 and 24 patients who underwent dilation and curettage at <10 weeks of gestation, due to first trimester spontaneous pregnancy loss and for elective termination (control), respectively. Placental and decidual tissues from all patients were sectioned and immunohistochemically analyzed for kisspeptin. RESULTS: Age, gravida status, parity number, gestational week, and number of previous abortions did not significantly differ between the groups. KISS-1 expression levels were significantly lower in the group with spontaneous abortion compared with the group with elective termination. The median staining intensity of KISS-1 expression in the elective and spontaneous termination groups were 3 (strong) and 2 (moderate), respectively (P=0.004). KISS-1 expression levels were significantly lower among patients with previous abortions in the elective termination group (P=0.002). CONCLUSION: KISS-1 expression levels were found to be significantly reduced in patients with spontaneous pregnancy loss; KISS-1 plays an important role in the implantation and continuation of pregnancy.
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spelling pubmed-73937442020-08-07 Is placental KISS-1 expression associated with first trimester abortion spontaneous? Colak, Eser Ozcimen, Emel Ebru Erinanç, Ozgur Hilal Tohma, Yusuf Aytac Ceran, Mehmet Ufuk Obstet Gynecol Sci Original Article OBJECTIVE: Several studies have examined biological markers during the first trimester to predict the maintenance of a healthy pregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether first-trimester pregnancy losses were associated with levels of placental KISS-1 expression. METHODS: This prospective case control study was conducted at a tertiary center. The study group included 27 and 24 patients who underwent dilation and curettage at <10 weeks of gestation, due to first trimester spontaneous pregnancy loss and for elective termination (control), respectively. Placental and decidual tissues from all patients were sectioned and immunohistochemically analyzed for kisspeptin. RESULTS: Age, gravida status, parity number, gestational week, and number of previous abortions did not significantly differ between the groups. KISS-1 expression levels were significantly lower in the group with spontaneous abortion compared with the group with elective termination. The median staining intensity of KISS-1 expression in the elective and spontaneous termination groups were 3 (strong) and 2 (moderate), respectively (P=0.004). KISS-1 expression levels were significantly lower among patients with previous abortions in the elective termination group (P=0.002). CONCLUSION: KISS-1 expression levels were found to be significantly reduced in patients with spontaneous pregnancy loss; KISS-1 plays an important role in the implantation and continuation of pregnancy. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2020-07 2020-07-01 /pmc/articles/PMC7393744/ /pubmed/32689775 http://dx.doi.org/10.5468/ogs.19242 Text en Copyright © 2020 Korean Society of Obstetrics and Gynecology Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Colak, Eser
Ozcimen, Emel Ebru
Erinanç, Ozgur Hilal
Tohma, Yusuf Aytac
Ceran, Mehmet Ufuk
Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title_full Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title_fullStr Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title_full_unstemmed Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title_short Is placental KISS-1 expression associated with first trimester abortion spontaneous?
title_sort is placental kiss-1 expression associated with first trimester abortion spontaneous?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393744/
https://www.ncbi.nlm.nih.gov/pubmed/32689775
http://dx.doi.org/10.5468/ogs.19242
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