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Role of matrix Metalloproteinases in pituitary adenoma invasion

Though pituitary adenomas are benign tumors in most cases, a considerable fraction of PAs behave in a malignant-like manner and invade to the adjacent structures in sellar region, especially the cavernous sinuses. Cancer-cell invasion and metastasis remain a great challenge for physicians and surgeo...

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Autores principales: Yang, Chengxian, Bao, Xinjie, Wang, Renzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393832/
https://www.ncbi.nlm.nih.gov/pubmed/32922863
http://dx.doi.org/10.1186/s41016-017-0109-0
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author Yang, Chengxian
Bao, Xinjie
Wang, Renzhi
author_facet Yang, Chengxian
Bao, Xinjie
Wang, Renzhi
author_sort Yang, Chengxian
collection PubMed
description Though pituitary adenomas are benign tumors in most cases, a considerable fraction of PAs behave in a malignant-like manner and invade to the adjacent structures in sellar region, especially the cavernous sinuses. Cancer-cell invasion and metastasis remain a great challenge for physicians and surgeons in spite of emerging advances in drug therapy and surgical Treatment. matrix metalloproteinases, as a family of zinc-dependent endopeptidases, have long been known to be associated with tumor invasion and metastasis mainly via breaking down basement membrane in different tissues. Aberrant expression and activation of matrix metalloproteinases have been detected in invasive pituitary adenomas as in malignancy and correlated to tumor invasion. Therefore, matrix metalloproteinases are considered as promising biomarkers for predicting tumor behavior and even drug targets for novel therapeutic strategies. In this review, we give an overview of the expression, function, regulation and clinical prospects of matrix metalloproteinases, especially focusing on the biological network in which matrix metalloproteinases may be abnormally activated in promoting pituitary adenoma invasion.
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spelling pubmed-73938322020-09-10 Role of matrix Metalloproteinases in pituitary adenoma invasion Yang, Chengxian Bao, Xinjie Wang, Renzhi Chin Neurosurg J Review Though pituitary adenomas are benign tumors in most cases, a considerable fraction of PAs behave in a malignant-like manner and invade to the adjacent structures in sellar region, especially the cavernous sinuses. Cancer-cell invasion and metastasis remain a great challenge for physicians and surgeons in spite of emerging advances in drug therapy and surgical Treatment. matrix metalloproteinases, as a family of zinc-dependent endopeptidases, have long been known to be associated with tumor invasion and metastasis mainly via breaking down basement membrane in different tissues. Aberrant expression and activation of matrix metalloproteinases have been detected in invasive pituitary adenomas as in malignancy and correlated to tumor invasion. Therefore, matrix metalloproteinases are considered as promising biomarkers for predicting tumor behavior and even drug targets for novel therapeutic strategies. In this review, we give an overview of the expression, function, regulation and clinical prospects of matrix metalloproteinases, especially focusing on the biological network in which matrix metalloproteinases may be abnormally activated in promoting pituitary adenoma invasion. BioMed Central 2018-02-09 /pmc/articles/PMC7393832/ /pubmed/32922863 http://dx.doi.org/10.1186/s41016-017-0109-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yang, Chengxian
Bao, Xinjie
Wang, Renzhi
Role of matrix Metalloproteinases in pituitary adenoma invasion
title Role of matrix Metalloproteinases in pituitary adenoma invasion
title_full Role of matrix Metalloproteinases in pituitary adenoma invasion
title_fullStr Role of matrix Metalloproteinases in pituitary adenoma invasion
title_full_unstemmed Role of matrix Metalloproteinases in pituitary adenoma invasion
title_short Role of matrix Metalloproteinases in pituitary adenoma invasion
title_sort role of matrix metalloproteinases in pituitary adenoma invasion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393832/
https://www.ncbi.nlm.nih.gov/pubmed/32922863
http://dx.doi.org/10.1186/s41016-017-0109-0
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