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Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

BACKGROUND: Identification of islet β cell death prior to the onset of type 1 diabetes (T1D) or type 2 diabetes (T2D) might allow for interventions to protect β cells and reduce diabetes risk. Circulating unmethylated DNA fragments arising from the human INS gene have been proposed as biomarkers of...

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Detalles Bibliográficos
Autores principales:	Syed, Farooq, Tersey, Sarah A., Turatsinze, Jean-Valery, Felton, Jamie L., Kang, Nicole Jiyun, Nelson, Jennifer B., Sims, Emily K., Defrance, Mathieu, Bizet, Martin, Fuks, Francois, Cnop, Miriam, Bugliani, Marco, Marchetti, Piero, Ziegler, Anette-Gabriele, Bonifacio, Ezio, Webb-Robertson, Bobbie-Jo, Balamurugan, Appakalai N., Evans-Molina, Carmella, Eizirik, Decio L., Mather, Kieren J., Arslanian, Silva, Mirmira, Raghavendra G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393900/ https://www.ncbi.nlm.nih.gov/pubmed/32736653 http://dx.doi.org/10.1186/s13148-020-00906-5

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