Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways

BACKGROUND: Mesenchymal stem cells (MSCs) have a limited self-renewal ability, impaired multi-differentiation potential, and undetermined cell senescence during in vitro series expansion. To address this concern, we investigated the effects of the microenvironment provided by stem cells from human e...

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Detalles Bibliográficos
Autores principales: Cao, Zeyuan, Xie, Yunyi, Yu, Le, Li, Yi, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393921/
https://www.ncbi.nlm.nih.gov/pubmed/32736659
http://dx.doi.org/10.1186/s13287-020-01830-4

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