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Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394049/ https://www.ncbi.nlm.nih.gov/pubmed/32737869 http://dx.doi.org/10.1007/s42770-020-00348-4 |
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author | da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina Fuentefria, Alexandre Meneghello |
author_facet | da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina Fuentefria, Alexandre Meneghello |
author_sort | da Rosa Monte Machado, Gabriella |
collection | PubMed |
description | Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml(−1))). However, compounds 2 (GM = 50 μg ml(−1)) and 3 (GM = 47.19 μg ml(−1)) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00348-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7394049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73940492020-07-31 Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina Fuentefria, Alexandre Meneghello Braz J Microbiol Clinical Microbiology - Research Paper Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml(−1))). However, compounds 2 (GM = 50 μg ml(−1)) and 3 (GM = 47.19 μg ml(−1)) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00348-4) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-07-31 /pmc/articles/PMC7394049/ /pubmed/32737869 http://dx.doi.org/10.1007/s42770-020-00348-4 Text en © Sociedade Brasileira de Microbiologia 2020 |
spellingShingle | Clinical Microbiology - Research Paper da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina Fuentefria, Alexandre Meneghello Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title | Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_full | Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_fullStr | Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_full_unstemmed | Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_short | Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_sort | quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
topic | Clinical Microbiology - Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394049/ https://www.ncbi.nlm.nih.gov/pubmed/32737869 http://dx.doi.org/10.1007/s42770-020-00348-4 |
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