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Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis

Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal pr...

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Autores principales: da Rosa Monte Machado, Gabriella, Diedrich, Denise, Ruaro, Thaís Carine, Zimmer, Aline Rigon, Lettieri Teixeira, Mário, de Oliveira, Luís Flávio, Jean, Mickael, Van de Weghe, Pierre, de Andrade, Saulo Fernandes, Baggio Gnoatto, Simone Cristina, Fuentefria, Alexandre Meneghello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394049/
https://www.ncbi.nlm.nih.gov/pubmed/32737869
http://dx.doi.org/10.1007/s42770-020-00348-4
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author da Rosa Monte Machado, Gabriella
Diedrich, Denise
Ruaro, Thaís Carine
Zimmer, Aline Rigon
Lettieri Teixeira, Mário
de Oliveira, Luís Flávio
Jean, Mickael
Van de Weghe, Pierre
de Andrade, Saulo Fernandes
Baggio Gnoatto, Simone Cristina
Fuentefria, Alexandre Meneghello
author_facet da Rosa Monte Machado, Gabriella
Diedrich, Denise
Ruaro, Thaís Carine
Zimmer, Aline Rigon
Lettieri Teixeira, Mário
de Oliveira, Luís Flávio
Jean, Mickael
Van de Weghe, Pierre
de Andrade, Saulo Fernandes
Baggio Gnoatto, Simone Cristina
Fuentefria, Alexandre Meneghello
author_sort da Rosa Monte Machado, Gabriella
collection PubMed
description Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml(−1))). However, compounds 2 (GM = 50 μg ml(−1)) and 3 (GM = 47.19 μg ml(−1)) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00348-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-73940492020-07-31 Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina Fuentefria, Alexandre Meneghello Braz J Microbiol Clinical Microbiology - Research Paper Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml(−1))). However, compounds 2 (GM = 50 μg ml(−1)) and 3 (GM = 47.19 μg ml(−1)) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00348-4) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-07-31 /pmc/articles/PMC7394049/ /pubmed/32737869 http://dx.doi.org/10.1007/s42770-020-00348-4 Text en © Sociedade Brasileira de Microbiologia 2020
spellingShingle Clinical Microbiology - Research Paper
da Rosa Monte Machado, Gabriella
Diedrich, Denise
Ruaro, Thaís Carine
Zimmer, Aline Rigon
Lettieri Teixeira, Mário
de Oliveira, Luís Flávio
Jean, Mickael
Van de Weghe, Pierre
de Andrade, Saulo Fernandes
Baggio Gnoatto, Simone Cristina
Fuentefria, Alexandre Meneghello
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title_full Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title_fullStr Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title_full_unstemmed Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title_short Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
title_sort quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
topic Clinical Microbiology - Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394049/
https://www.ncbi.nlm.nih.gov/pubmed/32737869
http://dx.doi.org/10.1007/s42770-020-00348-4
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