Cargando…

Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway

Wogonin, an active component derived from Scutellaria baicalensis, has shown anti-tumor activities in several malignancies. However, the roles of wogonin in RCC cells remain elusive. Here, we explored the effects of wogonin on RCC cells and the underlying mechanisms. We found that wogonin showed sig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yong, Chen, Shouzhen, Sun, Shuna, Liu, Guangyi, Chen, Lipeng, Xia, Yangyang, Cui, Jianfeng, Wang, Wenfu, Jiang, Xuewen, Zhang, Lei, Zhu, Yaofeng, Zou, Yongxin, Shi, Benkang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394056/ https://www.ncbi.nlm.nih.gov/pubmed/32792963 http://dx.doi.org/10.3389/fphar.2020.01152

Ejemplares similares

Comprehensive analysis of N(6)-methyladenosine regulators with the tumor immune landscape and correlation between the insulin-like growth factor 2 mRNA-binding protein 3 and programmed death ligand 1 in bladder cancer
por: Cui, Jianfeng, et al.
Publicado: (2022)

AB050. The role of c-met in the prognosis and clinicopathology of renal cell carcinoma: results from a single-center study and systematic review
por: Chen, Shouzhen, et al.
Publicado: (2016)

KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1
por: Liu, Lei, et al.
Publicado: (2021)

AB150. Paraneoplastic cerebellar degeneration: an uncommon manifestation of urothelial carcinoma in situ of the urinary bladder
por: Zhu, Yaofeng, et al.
Publicado: (2016)

AB258. Effect and mechanism of grape seed proanthocyanidin extract (GSPE) on diabetes-induced bladder dysfunction
por: Chen, Shouzhen, et al.
Publicado: (2016)

Arterioureteral fistula after radical cystectomy and ureterocutaneostomy: two case reports and a systematic literature review
por: Jiang, Zhiwen, et al.
Publicado: (2022)

AB048. Preoperative prognostic nutritional index and nomogram predicting recurrence-free survival in patients with primary non-muscle invasive bladder cancer without carcinoma in situ
por: Cui, Jianfeng, et al.
Publicado: (2017)

Preoperative prognostic nutritional index and nomogram predicting recurrence-free survival in patients with primary non-muscle-invasive bladder cancer without carcinoma in situ
por: Cui, Jianfeng, et al.
Publicado: (2017)

AB010. The clinical application of relevant local prostate anatomy in laparoscopic radical prostatectomy
por: Shi, Benkang, et al.
Publicado: (2017)

AB152. Combination of intravesical chemotherapy and Bacillus Calmette-Guerin versus Bacillus Calmette-Guerin monotherapy in intermediate- and high-risk non-muscle invasive bladder cancer: a systematic review and meta-analysis
por: Cui, Jianfeng, et al.
Publicado: (2016)

Diagnostic Efficiency of Pan-Immune-Inflammation Value to Predict Prostate Cancer in Patients with Prostate-Specific Antigen between 4 and 20 ng/mL
por: Zhu, Meikai, et al.
Publicado: (2023)

AB058. Therapeutic efficacy of trans-rectal triple physiotherapy combined with pharmacotherapy in comparison with pharmacotherapy alone in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)
por: Cheng, Shanshan, et al.
Publicado: (2017)

Nomograms Combining PHI and PI-RADS in Detecting Prostate Cancer: A Multicenter Prospective Study
por: Zhou, Yongheng, et al.
Publicado: (2023)

AB059. Pelvic floor reconstruction after radical prostatectomy: a systematic review and meta-analysis of different surgical techniques
por: Cui, Jianfeng, et al.
Publicado: (2017)

Revealing the prognostic and clinicopathological significance of systemic immune-inflammation index in patients with different stage prostate cancer: A systematic review and meta-analysis
por: Qi, Wenqiang, et al.
Publicado: (2022)

AB256. Grape seed proanthocyanidin extract attenuates varicocele-induced testicular oxidative injury in rats by activating the Nrf2-antioxidant system
por: Wang, Yong, et al.
Publicado: (2016)

Combination of Intravesical Chemotherapy and Bacillus Calmette–Guerin Versus Bacillus Calmette–Guerin Monotherapy in Intermediate- and High-risk Nonmuscle Invasive Bladder Cancer: A Systematic Review and Meta-analysis
por: Cui, Jianfeng, et al.
Publicado: (2016)

AB257. The study of the influence of the changes in alpha 1-adrenergic receptor and NGF on the diabetic urethral function
por: Chen, Shouzhen, et al.
Publicado: (2016)

AB151. Meta-analysis: comparison of partial nephrectomy and radiofrequency ablation in small renal tumors
por: Yang, Yue, et al.
Publicado: (2016)

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
por: Polier, G, et al.
Publicado: (2011)

AB149. Is two-layer suture necessary in laparoscopic partial nephrectomy?
por: Chen, Fan, et al.
Publicado: (2016)

Therapy Effects of Wogonin on Ovarian Cancer Cells
por: Ruibin, Jiang, et al.
Publicado: (2017)

Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study
por: Cui, Jianfeng, et al.
Publicado: (2017)

Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells
por: Wang, Lei, et al.
Publicado: (2012)

Construction and Comparison of Different Models in Detecting Prostate Cancer and Clinically Significant Prostate Cancer
por: Zhou, Yongheng, et al.
Publicado: (2022)

Comparison of a Personalized Prostate Biopsy Pattern With Traditional Transrectal Prostate Biopsy: Different Cancer Detection Rate
por: Jiang, Xin, et al.
Publicado: (2022)

AB260. Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats
por: Zhang, Zhaocun, et al.
Publicado: (2016)

Cdk6: At the interface of Rb and p53
por: Nebenfuehr, Sofie, et al.
Publicado: (2018)

Grape Seed Proanthocyanidin Extract Ameliorates Diabetic Bladder Dysfunction via the Activation of the Nrf2 Pathway
por: Chen, Shouzhen, et al.
Publicado: (2015)

AB047. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study
por: Cai, Jianfeng, et al.
Publicado: (2017)

Effect of magnetic nanoparticles of Fe(3)O(4) and wogonin on the reversal of multidrug resistance in K562/A02 cell line
por: Cheng, Jian, et al.
Publicado: (2012)

Reversal of Cushing Pigmentation by Sunitinib
por: Iwasaki, Yorihiro, et al.
Publicado: (2019)

Nociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections
por: Gao, Zhengdong, et al.
Publicado: (2022)

An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review
por: Zhu, Yaofeng, et al.
Publicado: (2016)

BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin
por: Xu, Xuefen, et al.
Publicado: (2016)

Pelvic Floor Reconstruction After Radical Prostatectomy: A Systematic Review and Meta-analysis of Different Surgical Techniques
por: Cui, Jianfeng, et al.
Publicado: (2017)

Current biological and pharmacological updates on wogonin
por: Rawat, Sarita, et al.
Publicado: (2020)

Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma
por: Cui, Jianfeng, et al.
Publicado: (2017)

Profiles of Immune Infiltration in Bladder Cancer and its Clinical Significance: an Integrative Genomic Analysis
por: Wu, Zonglong, et al.
Publicado: (2020)

CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition
por: Kim, Sungsoo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9ijik7ovlhbu6tm4okdrup664b