Microglial microRNAs mediate sex-specific responses to tau pathology

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females and that loss...

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Autores principales: Kodama, Lay, Guzman, Elmer, Etchegaray, Jon I., Li, Yaqiao, Sayed, Faten A., Zhou, Lu, Zhou, Yungui, Zhan, Lihong, Le, David, Udeochu, Joe C., Clelland, Claire D., Cheng, Zuolin, Yu, Guoqiang, Li, Qingyun, Kosik, Kenneth S., Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394069/
https://www.ncbi.nlm.nih.gov/pubmed/31873194
http://dx.doi.org/10.1038/s41593-019-0560-7
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author Kodama, Lay
Guzman, Elmer
Etchegaray, Jon I.
Li, Yaqiao
Sayed, Faten A.
Zhou, Lu
Zhou, Yungui
Zhan, Lihong
Le, David
Udeochu, Joe C.
Clelland, Claire D.
Cheng, Zuolin
Yu, Guoqiang
Li, Qingyun
Kosik, Kenneth S.
Gan, Li
author_facet Kodama, Lay
Guzman, Elmer
Etchegaray, Jon I.
Li, Yaqiao
Sayed, Faten A.
Zhou, Lu
Zhou, Yungui
Zhan, Lihong
Le, David
Udeochu, Joe C.
Clelland, Claire D.
Cheng, Zuolin
Yu, Guoqiang
Li, Qingyun
Kosik, Kenneth S.
Gan, Li
author_sort Kodama, Lay
collection PubMed
description Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females and that loss of miRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest microglial miRNAs influence tau pathogenesis in a sex-specific manner.
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spelling pubmed-73940692020-07-31 Microglial microRNAs mediate sex-specific responses to tau pathology Kodama, Lay Guzman, Elmer Etchegaray, Jon I. Li, Yaqiao Sayed, Faten A. Zhou, Lu Zhou, Yungui Zhan, Lihong Le, David Udeochu, Joe C. Clelland, Claire D. Cheng, Zuolin Yu, Guoqiang Li, Qingyun Kosik, Kenneth S. Gan, Li Nat Neurosci Article Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females and that loss of miRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest microglial miRNAs influence tau pathogenesis in a sex-specific manner. 2019-12-23 2020-02 /pmc/articles/PMC7394069/ /pubmed/31873194 http://dx.doi.org/10.1038/s41593-019-0560-7 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kodama, Lay
Guzman, Elmer
Etchegaray, Jon I.
Li, Yaqiao
Sayed, Faten A.
Zhou, Lu
Zhou, Yungui
Zhan, Lihong
Le, David
Udeochu, Joe C.
Clelland, Claire D.
Cheng, Zuolin
Yu, Guoqiang
Li, Qingyun
Kosik, Kenneth S.
Gan, Li
Microglial microRNAs mediate sex-specific responses to tau pathology
title Microglial microRNAs mediate sex-specific responses to tau pathology
title_full Microglial microRNAs mediate sex-specific responses to tau pathology
title_fullStr Microglial microRNAs mediate sex-specific responses to tau pathology
title_full_unstemmed Microglial microRNAs mediate sex-specific responses to tau pathology
title_short Microglial microRNAs mediate sex-specific responses to tau pathology
title_sort microglial micrornas mediate sex-specific responses to tau pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394069/
https://www.ncbi.nlm.nih.gov/pubmed/31873194
http://dx.doi.org/10.1038/s41593-019-0560-7
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