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Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

INTRODUCTION: Increased oxidative stress (OXS) and a high prevalence of psychiatric disorders are seen in alopecia areata (AA). However, OXS and psychiatric disorders have been studied separately in AA patients. AIM: To determine the effects of anxiety and depression symptoms on OXS in AA patients....

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Autores principales: Cakirca, Gokhan, Manav, Vildan, Celik, Hakim, Saracoglu, Gülben, Yetkin, Esra Nur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394168/
https://www.ncbi.nlm.nih.gov/pubmed/32792885
http://dx.doi.org/10.5114/ada.2019.83879
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author Cakirca, Gokhan
Manav, Vildan
Celik, Hakim
Saracoglu, Gülben
Yetkin, Esra Nur
author_facet Cakirca, Gokhan
Manav, Vildan
Celik, Hakim
Saracoglu, Gülben
Yetkin, Esra Nur
author_sort Cakirca, Gokhan
collection PubMed
description INTRODUCTION: Increased oxidative stress (OXS) and a high prevalence of psychiatric disorders are seen in alopecia areata (AA). However, OXS and psychiatric disorders have been studied separately in AA patients. AIM: To determine the effects of anxiety and depression symptoms on OXS in AA patients. MATERIAL AND METHODS: The anxiety and depression levels of 33 AA patients and 33 normal controls (NC) were determined using the Hospital Anxiety and Depression Scale. The oxidative stress index (OSI) was calculated by measuring serum total antioxidant status (TAS) and total oxidant status (TOS) levels in AA patients and NC. RESULTS: The AA patients had higher anxiety and depression scores than NC (p < 0.001 for both). Total oxidant status (p = 0.002) and OSI (p < 0.001) values were higher, and TAS (p < 0.001) levels were lower, in patients with AA compared to NC. However, patients’ anxiety and depression scores were not correlated with the TAS, TOS, or OSI values (p > 0.05). There was no significant difference in TAS, TOS, or OSI values between patients with high and low anxiety or depression scores (p > 0.05). CONCLUSIONS: These results show that OXS, anxiety, and depression scores were higher in patients with AA compared to NC. However, anxiety and depression scores were not associated with OXS in AA patients. More extensive studies should be performed to investigate the relationship between psychological status and OXS in patients with AA.
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spelling pubmed-73941682020-08-12 Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata Cakirca, Gokhan Manav, Vildan Celik, Hakim Saracoglu, Gülben Yetkin, Esra Nur Postepy Dermatol Alergol Original Paper INTRODUCTION: Increased oxidative stress (OXS) and a high prevalence of psychiatric disorders are seen in alopecia areata (AA). However, OXS and psychiatric disorders have been studied separately in AA patients. AIM: To determine the effects of anxiety and depression symptoms on OXS in AA patients. MATERIAL AND METHODS: The anxiety and depression levels of 33 AA patients and 33 normal controls (NC) were determined using the Hospital Anxiety and Depression Scale. The oxidative stress index (OSI) was calculated by measuring serum total antioxidant status (TAS) and total oxidant status (TOS) levels in AA patients and NC. RESULTS: The AA patients had higher anxiety and depression scores than NC (p < 0.001 for both). Total oxidant status (p = 0.002) and OSI (p < 0.001) values were higher, and TAS (p < 0.001) levels were lower, in patients with AA compared to NC. However, patients’ anxiety and depression scores were not correlated with the TAS, TOS, or OSI values (p > 0.05). There was no significant difference in TAS, TOS, or OSI values between patients with high and low anxiety or depression scores (p > 0.05). CONCLUSIONS: These results show that OXS, anxiety, and depression scores were higher in patients with AA compared to NC. However, anxiety and depression scores were not associated with OXS in AA patients. More extensive studies should be performed to investigate the relationship between psychological status and OXS in patients with AA. Termedia Publishing House 2019-03-26 2020-06 /pmc/articles/PMC7394168/ /pubmed/32792885 http://dx.doi.org/10.5114/ada.2019.83879 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Cakirca, Gokhan
Manav, Vildan
Celik, Hakim
Saracoglu, Gülben
Yetkin, Esra Nur
Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title_full Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title_fullStr Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title_full_unstemmed Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title_short Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
title_sort effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394168/
https://www.ncbi.nlm.nih.gov/pubmed/32792885
http://dx.doi.org/10.5114/ada.2019.83879
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