A rare case of tuberculosis-induced hypercalcemia

Laboratory investigations of hypercalcemia involve testing of various biochemical parameters such as parathyroid hormone (PTH), 25-(OH) Vitamin D (25-(OH) VitD), 1,25-(OH)(2) Vitamin D3 (calcitriol) and PTH related peptide (PTHrp). We herein present an atypical case of severe hypercalcemia in a pati...

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Detalles Bibliográficos
Autores principales: Wauthier, Loris, Theunssens, Xavier, Durez, Patrick, Fillée, Catherine, Maisin, Diane, Gruson, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394250/
https://www.ncbi.nlm.nih.gov/pubmed/32774126
http://dx.doi.org/10.11613/BM.2020.030801
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author Wauthier, Loris
Theunssens, Xavier
Durez, Patrick
Fillée, Catherine
Maisin, Diane
Gruson, Damien
author_facet Wauthier, Loris
Theunssens, Xavier
Durez, Patrick
Fillée, Catherine
Maisin, Diane
Gruson, Damien
author_sort Wauthier, Loris
collection PubMed
description Laboratory investigations of hypercalcemia involve testing of various biochemical parameters such as parathyroid hormone (PTH), 25-(OH) Vitamin D (25-(OH) VitD), 1,25-(OH)(2) Vitamin D3 (calcitriol) and PTH related peptide (PTHrp). We herein present an atypical case of severe hypercalcemia in a patient with rheumatoid arthritis who has been treated for years by various biological disease-modifying antirheumatic drugs (DMARDs) and suddenly presented with general state alteration, oedema and ulceration of her right ankle. We illustrate how tuberculosis (TB) can cause high calcitriol concentration and subsequently lead to potentially severe hypercalcemia. Moreover, we highlight the importance of TB testing and follow-up in patients treated with biological DMARDs.
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spelling pubmed-73942502020-08-08 A rare case of tuberculosis-induced hypercalcemia Wauthier, Loris Theunssens, Xavier Durez, Patrick Fillée, Catherine Maisin, Diane Gruson, Damien Biochem Med (Zagreb) Case Report Laboratory investigations of hypercalcemia involve testing of various biochemical parameters such as parathyroid hormone (PTH), 25-(OH) Vitamin D (25-(OH) VitD), 1,25-(OH)(2) Vitamin D3 (calcitriol) and PTH related peptide (PTHrp). We herein present an atypical case of severe hypercalcemia in a patient with rheumatoid arthritis who has been treated for years by various biological disease-modifying antirheumatic drugs (DMARDs) and suddenly presented with general state alteration, oedema and ulceration of her right ankle. We illustrate how tuberculosis (TB) can cause high calcitriol concentration and subsequently lead to potentially severe hypercalcemia. Moreover, we highlight the importance of TB testing and follow-up in patients treated with biological DMARDs. Croatian Society of Medical Biochemistry and Laboratory Medicine 2020-08-05 2020-10-15 /pmc/articles/PMC7394250/ /pubmed/32774126 http://dx.doi.org/10.11613/BM.2020.030801 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wauthier, Loris
Theunssens, Xavier
Durez, Patrick
Fillée, Catherine
Maisin, Diane
Gruson, Damien
A rare case of tuberculosis-induced hypercalcemia
title A rare case of tuberculosis-induced hypercalcemia
title_full A rare case of tuberculosis-induced hypercalcemia
title_fullStr A rare case of tuberculosis-induced hypercalcemia
title_full_unstemmed A rare case of tuberculosis-induced hypercalcemia
title_short A rare case of tuberculosis-induced hypercalcemia
title_sort rare case of tuberculosis-induced hypercalcemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394250/
https://www.ncbi.nlm.nih.gov/pubmed/32774126
http://dx.doi.org/10.11613/BM.2020.030801
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