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SARS-CoV-2 – a new challenge for laboratory medicine
The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or cond...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Croatian Society of Medical Biochemistry and Laboratory Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394259/ https://www.ncbi.nlm.nih.gov/pubmed/32774121 http://dx.doi.org/10.11613/BM.2020.030503 |
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author | Dodig, Slavica Čepelak, Ivana Čepelak Dodig, Daniela Laškaj, Renata |
author_facet | Dodig, Slavica Čepelak, Ivana Čepelak Dodig, Daniela Laškaj, Renata |
author_sort | Dodig, Slavica |
collection | PubMed |
description | The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or condition. The reasons for this should be sought in the processes of aging and chronic latent inflammation, i.e. immunosenescence and inflammaging. Laboratory medicine specialists are currently focused on proving the presence of the virus and defining biomarkers that would enable the prediction of disease progression. For now, it has been shown that useful biomarkers can include general biomarkers of inflammation (parameters of complete blood count, C-reactive protein, interleukin-6, procalcitonin), biomarkers of myocardial damage (high sensitivity troponin I/T, B-type natriuretic peptide, and N-terminal B type natriuretic peptide), and vascular biomarkers (D-dimer, prothrombin time, fibrinogen). Their actual diagnostic specificity, sensitivity and predictive value need to be tested on a larger number of subjects. In addition, it is important to find and evaluate specific biomarkers of immunosenescence. |
format | Online Article Text |
id | pubmed-7394259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Croatian Society of Medical Biochemistry and Laboratory Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-73942592020-08-08 SARS-CoV-2 – a new challenge for laboratory medicine Dodig, Slavica Čepelak, Ivana Čepelak Dodig, Daniela Laškaj, Renata Biochem Med (Zagreb) Review The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or condition. The reasons for this should be sought in the processes of aging and chronic latent inflammation, i.e. immunosenescence and inflammaging. Laboratory medicine specialists are currently focused on proving the presence of the virus and defining biomarkers that would enable the prediction of disease progression. For now, it has been shown that useful biomarkers can include general biomarkers of inflammation (parameters of complete blood count, C-reactive protein, interleukin-6, procalcitonin), biomarkers of myocardial damage (high sensitivity troponin I/T, B-type natriuretic peptide, and N-terminal B type natriuretic peptide), and vascular biomarkers (D-dimer, prothrombin time, fibrinogen). Their actual diagnostic specificity, sensitivity and predictive value need to be tested on a larger number of subjects. In addition, it is important to find and evaluate specific biomarkers of immunosenescence. Croatian Society of Medical Biochemistry and Laboratory Medicine 2020-08-05 2020-10-15 /pmc/articles/PMC7394259/ /pubmed/32774121 http://dx.doi.org/10.11613/BM.2020.030503 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Dodig, Slavica Čepelak, Ivana Čepelak Dodig, Daniela Laškaj, Renata SARS-CoV-2 – a new challenge for laboratory medicine |
title | SARS-CoV-2 – a new challenge for laboratory medicine |
title_full | SARS-CoV-2 – a new challenge for laboratory medicine |
title_fullStr | SARS-CoV-2 – a new challenge for laboratory medicine |
title_full_unstemmed | SARS-CoV-2 – a new challenge for laboratory medicine |
title_short | SARS-CoV-2 – a new challenge for laboratory medicine |
title_sort | sars-cov-2 – a new challenge for laboratory medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394259/ https://www.ncbi.nlm.nih.gov/pubmed/32774121 http://dx.doi.org/10.11613/BM.2020.030503 |
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