Diverse dynamics features of novel protein kinase C (PKC) isozymes determine the selectivity of a fluorinated balanol analogue for PKCε

BACKGROUND: (−)-Balanol is an ATP-mimicking inhibitor that non-selectively targets protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA). While PKA constantly shows tumor promoting activities, PKC isozymes can ambiguously be tumor promoters or suppressors. In particular, PKCε is fr...

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Detalles Bibliográficos
Autores principales: Hardianto, Ari, Khanna, Varun, Liu, Fei, Ranganathan, Shoba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394325/
https://www.ncbi.nlm.nih.gov/pubmed/30717648
http://dx.doi.org/10.1186/s12859-018-2373-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394325/
https://www.ncbi.nlm.nih.gov/pubmed/30717648
http://dx.doi.org/10.1186/s12859-018-2373-1

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