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Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study

Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However...

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Autores principales: Ma, Zhonghua, Jiang, Hanqiu, Meng, Chao, Cui, Shilei, Peng, Jingting, Wang, Jiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394431/
https://www.ncbi.nlm.nih.gov/pubmed/32735573
http://dx.doi.org/10.1371/journal.pone.0236828
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author Ma, Zhonghua
Jiang, Hanqiu
Meng, Chao
Cui, Shilei
Peng, Jingting
Wang, Jiawei
author_facet Ma, Zhonghua
Jiang, Hanqiu
Meng, Chao
Cui, Shilei
Peng, Jingting
Wang, Jiawei
author_sort Ma, Zhonghua
collection PubMed
description Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes.
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spelling pubmed-73944312020-08-07 Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study Ma, Zhonghua Jiang, Hanqiu Meng, Chao Cui, Shilei Peng, Jingting Wang, Jiawei PLoS One Research Article Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes. Public Library of Science 2020-07-31 /pmc/articles/PMC7394431/ /pubmed/32735573 http://dx.doi.org/10.1371/journal.pone.0236828 Text en © 2020 Ma et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ma, Zhonghua
Jiang, Hanqiu
Meng, Chao
Cui, Shilei
Peng, Jingting
Wang, Jiawei
Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title_full Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title_fullStr Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title_full_unstemmed Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title_short Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
title_sort idiopathic intracranial hypertension in patients with anemia: a retrospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394431/
https://www.ncbi.nlm.nih.gov/pubmed/32735573
http://dx.doi.org/10.1371/journal.pone.0236828
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