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Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1(-/-) mouse model

There is a significant unmet need for a safe and effective therapy for the treatment of children with congenital hyperinsulinism. We hypothesized that amplification of the glucagon signaling pathway could ameliorate hyperinsulinism associated hypoglycemia. In order to test this we evaluated the effe...

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Detalles Bibliográficos
Autores principales:	Soundarapandian, Mangala M., Juliana, Christine A., Chai, Jinghua, Haslett, Patrick A., Fitzgerald, Kevin, De León, Diva D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394442/ https://www.ncbi.nlm.nih.gov/pubmed/32735622 http://dx.doi.org/10.1371/journal.pone.0236892

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