Cargando…

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1(-/-) mouse model

There is a significant unmet need for a safe and effective therapy for the treatment of children with congenital hyperinsulinism. We hypothesized that amplification of the glucagon signaling pathway could ameliorate hyperinsulinism associated hypoglycemia. In order to test this we evaluated the effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soundarapandian, Mangala M., Juliana, Christine A., Chai, Jinghua, Haslett, Patrick A., Fitzgerald, Kevin, De León, Diva D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394442/ https://www.ncbi.nlm.nih.gov/pubmed/32735622 http://dx.doi.org/10.1371/journal.pone.0236892

Ejemplares similares

The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
por: Danowitz, Melinda, et al.
Publicado: (2022)

Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient
por: Banerjee, Indraneel, et al.
Publicado: (2017)

A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism
por: Juliana, Christine A., et al.
Publicado: (2023)

Continuous Glucose Monitoring in the Management of Neonates With Persistent Hypoglycemia and Congenital Hyperinsulinism
por: Win, Myat, et al.
Publicado: (2021)

Congenital hyperinsulinism—A case of mild hypoglycemia in an adult, detected by family testing
por: Baleanu, Felicia, et al.
Publicado: (2022)

Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations
por: Li, Changhong, et al.
Publicado: (2023)

Insight into hypoglycemia frequency in congenital hyperinsulinism: evaluation of a large UK CGM dataset
por: Worth, Chris, et al.
Publicado: (2022)

Congenital hyperinsulinism in infancy and childhood: challenges, unmet needs and the perspective of patients and families
por: Banerjee, Indraneel, et al.
Publicado: (2022)

Correction to: Congenital hyperinsulinism in infancy and childhood: challenges, unmet needs and the perspective of patients and families
por: Banerjee, Indraneel, et al.
Publicado: (2022)

Congenital intrahepatic portocaval shunts and hypoglycemia due to secondary hyperinsulinism: a case report and review of the literature
por: Weigert, Alexander, et al.
Publicado: (2018)

Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the β-Cell Sulfonylurea Receptor SUR1
por: MacMullen, Courtney M., et al.
Publicado: (2011)

Familial Focal Congenital Hyperinsulinism
por: Ismail, Dunia, et al.
Publicado: (2011)

Global Registries in Congenital Hyperinsulinism
por: Pasquini, Tai L. S., et al.
Publicado: (2022)

Syndromic forms of congenital hyperinsulinism
por: Zenker, Martin, et al.
Publicado: (2023)

Congenital Hyperinsulinism International: A Community Focused on Improving the Lives of People Living With Congenital Hyperinsulinism
por: Raskin, Julie, et al.
Publicado: (2022)

Sirolimus treatment of severe congenital hyperinsulinism
por: Amato, Lisa A, et al.
Publicado: (2015)

Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulinism During Fasting and During a Meal and a Protein Challenge
por: Stefanovski, Darko, et al.
Publicado: (2022)

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism
por: Peterson, Sean M., et al.
Publicado: (2023)

A Case Series: Congenital Hyperinsulinism
por: Alaei, Mohammad Reza, et al.
Publicado: (2016)

Congenital Hyperinsulinism: Diagnosis and Treatment Update
por: Demirbilek, Hüseyin, et al.
Publicado: (2017)

The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism
por: Galcheva, Sonya, et al.
Publicado: (2019)

Clinical practice guidelines for congenital hyperinsulinism
por: Yorifuji, Tohru, et al.
Publicado: (2017)

Novel dominant K(ATP) channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping
por: Boodhansingh, Kara E., et al.
Publicado: (2019)

Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events
por: Rosenfeld, Elizabeth, et al.
Publicado: (2021)

Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017–2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)
por: Yamada, Yuki, et al.
Publicado: (2019)

Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome
por: Rosenfeld, Elizabeth, et al.
Publicado: (2022)

Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome
por: Boodhansingh, Kara E., et al.
Publicado: (2022)

Congenital hyperinsulinism: current trends in diagnosis and therapy
por: Arnoux, Jean-Baptiste, et al.
Publicado: (2011)

Congenital hyperinsulinism: current status and future perspectives
por: Yorifuji, Tohru
Publicado: (2014)

The molecular mechanisms, diagnosis and management of congenital hyperinsulinism
por: Senniappan, Senthil, et al.
Publicado: (2013)

Nifedipine in Congenital Hyperinsulinism- A Case Report
por: Khawash, Papiya, et al.
Publicado: (2015)

Therapies and outcomes of congenital hyperinsulinism‐induced hypoglycaemia
por: Banerjee, I., et al.
Publicado: (2018)

Possible New Strategies for the Treatment of Congenital Hyperinsulinism
por: Sikimic, Jelena, et al.
Publicado: (2020)

Clinical Efficacy Evaluation of Sirolimus in Congenital Hyperinsulinism
por: Hashemian, Somayyeh, et al.
Publicado: (2020)

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside
por: van Albada, Mirjam E., et al.
Publicado: (2022)

Congenital hyperinsulinism and panhypopituitarism: a rare combination
por: Patel, Foram, et al.
Publicado: (2023)

GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K(+) Channel
por: Calabria, Andrew C., et al.
Publicado: (2012)

New approaches to screening and management of neonatal hypoglycemia based on improved understanding of the molecular mechanism of hypoglycemia
por: Stanley, Charles A., et al.
Publicado: (2023)

Congenital hyperinsulinism in a newborn presenting with poor feeding
por: Mazloom, Kiran, et al.
Publicado: (2022)

Correction: Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome
por: Rosenfeld, Elizabeth, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nghlam4vdk1a9ek8abb46vo6i2