Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila. Heterozygous null mutations in each autism gene are demonstrated to have no...

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Detalles Bibliográficos
Autores principales: Genç, Özgür, An, Joon-Yong, Fetter, Richard D, Kulik, Yelena, Zunino, Giulia, Sanders, Stephan J, Davis, Graeme W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394548/
https://www.ncbi.nlm.nih.gov/pubmed/32609087
http://dx.doi.org/10.7554/eLife.55775

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