miR-3609 Decelerates the Clearance of Sorafenib in Hepatocellular Carcinoma Cells by Targeting EPAS-1 and Reducing the Activation of the Pregnane X Receptor Pathway

BACKGROUND: The pregnane X receptor (PXR) not only plays an important role in cellular metabolism processes but also induces the resistance of hepatocellular carcinoma (HCC) cells to molecularly targeted drugs by mediating their metabolism and clearance by these cells. Endothelial PAS domain-contain...

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Detalles Bibliográficos
Autores principales: Shao, Qing-Ping, Wei, Chen, Yang, Jie, Zhang, Wen-Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394586/
https://www.ncbi.nlm.nih.gov/pubmed/32801751
http://dx.doi.org/10.2147/OTT.S246471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394586/
https://www.ncbi.nlm.nih.gov/pubmed/32801751
http://dx.doi.org/10.2147/OTT.S246471

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