Cargando…

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsenin...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Juanjuan, Lu, Dan, Ren, Jia, Wen, Qiao, Zhou, Jing, Gan, Weigang, Liu, Jun, Liu, Shixi, Yang, Hui, Zou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394691/
https://www.ncbi.nlm.nih.gov/pubmed/32736545
http://dx.doi.org/10.1186/s12893-020-00831-7
_version_ 1783565271549607936
author Hu, Juanjuan
Lu, Dan
Ren, Jia
Wen, Qiao
Zhou, Jing
Gan, Weigang
Liu, Jun
Liu, Shixi
Yang, Hui
Zou, Jian
author_facet Hu, Juanjuan
Lu, Dan
Ren, Jia
Wen, Qiao
Zhou, Jing
Gan, Weigang
Liu, Jun
Liu, Shixi
Yang, Hui
Zou, Jian
author_sort Hu, Juanjuan
collection PubMed
description BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. CONCLUSIONS: Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor.
format Online
Article
Text
id pubmed-7394691
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-73946912020-08-05 Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review Hu, Juanjuan Lu, Dan Ren, Jia Wen, Qiao Zhou, Jing Gan, Weigang Liu, Jun Liu, Shixi Yang, Hui Zou, Jian BMC Surg Case Report BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. CONCLUSIONS: Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor. BioMed Central 2020-07-31 /pmc/articles/PMC7394691/ /pubmed/32736545 http://dx.doi.org/10.1186/s12893-020-00831-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Hu, Juanjuan
Lu, Dan
Ren, Jia
Wen, Qiao
Zhou, Jing
Gan, Weigang
Liu, Jun
Liu, Shixi
Yang, Hui
Zou, Jian
Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title_full Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title_fullStr Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title_full_unstemmed Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title_short Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
title_sort adult laryngeal embryonal rhabdomyosarcoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394691/
https://www.ncbi.nlm.nih.gov/pubmed/32736545
http://dx.doi.org/10.1186/s12893-020-00831-7
work_keys_str_mv AT hujuanjuan adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT ludan adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT renjia adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT wenqiao adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT zhoujing adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT ganweigang adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT liujun adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT liushixi adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT yanghui adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview
AT zoujian adultlaryngealembryonalrhabdomyosarcomaacasereportandliteraturereview