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Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsenin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394691/ https://www.ncbi.nlm.nih.gov/pubmed/32736545 http://dx.doi.org/10.1186/s12893-020-00831-7 |
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author | Hu, Juanjuan Lu, Dan Ren, Jia Wen, Qiao Zhou, Jing Gan, Weigang Liu, Jun Liu, Shixi Yang, Hui Zou, Jian |
author_facet | Hu, Juanjuan Lu, Dan Ren, Jia Wen, Qiao Zhou, Jing Gan, Weigang Liu, Jun Liu, Shixi Yang, Hui Zou, Jian |
author_sort | Hu, Juanjuan |
collection | PubMed |
description | BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. CONCLUSIONS: Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor. |
format | Online Article Text |
id | pubmed-7394691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73946912020-08-05 Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review Hu, Juanjuan Lu, Dan Ren, Jia Wen, Qiao Zhou, Jing Gan, Weigang Liu, Jun Liu, Shixi Yang, Hui Zou, Jian BMC Surg Case Report BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION: A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. CONCLUSIONS: Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor. BioMed Central 2020-07-31 /pmc/articles/PMC7394691/ /pubmed/32736545 http://dx.doi.org/10.1186/s12893-020-00831-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Hu, Juanjuan Lu, Dan Ren, Jia Wen, Qiao Zhou, Jing Gan, Weigang Liu, Jun Liu, Shixi Yang, Hui Zou, Jian Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title | Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title_full | Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title_fullStr | Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title_full_unstemmed | Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title_short | Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review |
title_sort | adult laryngeal embryonal rhabdomyosarcoma: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394691/ https://www.ncbi.nlm.nih.gov/pubmed/32736545 http://dx.doi.org/10.1186/s12893-020-00831-7 |
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