Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana

The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A (CsA) primarily at the 4th N-methyl leucine (MeLeu(4)), giving rise to γ-hydroxy-N-methyl-l-Leu(4)-CsA (CsA-4-OH). This oxidative modificatio...

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Detalles Bibliográficos
Autores principales: Li, Fengwei, Ma, Li, Zhang, Xingwang, Chen, Jingfei, Qi, Feifei, Huang, Yinyue, Qu, Zepeng, Yao, Lishan, Zhang, Wei, Kim, Eung-Soo, Li, Shengying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394738/
https://www.ncbi.nlm.nih.gov/pubmed/32775708
http://dx.doi.org/10.1016/j.synbio.2020.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394738/
https://www.ncbi.nlm.nih.gov/pubmed/32775708
http://dx.doi.org/10.1016/j.synbio.2020.07.004

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