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Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana
The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A (CsA) primarily at the 4th N-methyl leucine (MeLeu(4)), giving rise to γ-hydroxy-N-methyl-l-Leu(4)-CsA (CsA-4-OH). This oxidative modificatio...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394738/ https://www.ncbi.nlm.nih.gov/pubmed/32775708 http://dx.doi.org/10.1016/j.synbio.2020.07.004 |