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Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression
Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila. Functi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394757/ https://www.ncbi.nlm.nih.gov/pubmed/32736066 http://dx.doi.org/10.1016/j.isci.2020.101369 |