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E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion
Inhalation of aerosolized products generated by different electronic devices is called vaping. E-cigarettes or Vaping product use Associated Lung Injury (EVALI) outbreak peaked in August–September 2019 and gradually declined. EVALI remains a diagnosis of exclusion which presents as an acute lung inj...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394920/ https://www.ncbi.nlm.nih.gov/pubmed/32775191 http://dx.doi.org/10.1016/j.rmcr.2020.101174 |
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author | Mughal, Mohsin Sheraz Dalmacion, Denise Lauren V. Mirza, Hasan Mahmood Kaur, Ikwinder Preet Dela Cruz, Maria Amanda Kramer, Violet E. |
author_facet | Mughal, Mohsin Sheraz Dalmacion, Denise Lauren V. Mirza, Hasan Mahmood Kaur, Ikwinder Preet Dela Cruz, Maria Amanda Kramer, Violet E. |
author_sort | Mughal, Mohsin Sheraz |
collection | PubMed |
description | Inhalation of aerosolized products generated by different electronic devices is called vaping. E-cigarettes or Vaping product use Associated Lung Injury (EVALI) outbreak peaked in August–September 2019 and gradually declined. EVALI remains a diagnosis of exclusion which presents as an acute lung injury in the vaping population. Vitamin E acetate and its products are implicated as one of the cytotoxic agents causing airway centered pneumonitis. Lipid laden macrophages are found in samples of BAL fluid but their role in cytopathology of the disease remains unclear. We present a 57 years old man who came to the emergency department at Monmouth Medical Center, New Jersey in fall, 2019. Reportedly he has been vaping THC about 100g every day for past three days. At initial presentation, he had fever, shortness of breath and hypoxia requiring supplemental oxygen. He was empirically treated with levofloxacin 500 mg for five days without a significant improvement in his symptoms. Non-contrast chest CT scan showed bilateral ground-glass opacities, indicative of diffuse alveolar damage. He underwent flexible bronchoscopy to rule out infective pneumonia followed by auto-immune work-up that was non-conclusive. He was given 1 mg/kg methylprednisolone with a quick taper of oral steroids leading to the resolution of symptoms. At six months follow-up, imaging showed near resolution of ground-glass opacities. |
format | Online Article Text |
id | pubmed-7394920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73949202020-08-06 E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion Mughal, Mohsin Sheraz Dalmacion, Denise Lauren V. Mirza, Hasan Mahmood Kaur, Ikwinder Preet Dela Cruz, Maria Amanda Kramer, Violet E. Respir Med Case Rep Case Report Inhalation of aerosolized products generated by different electronic devices is called vaping. E-cigarettes or Vaping product use Associated Lung Injury (EVALI) outbreak peaked in August–September 2019 and gradually declined. EVALI remains a diagnosis of exclusion which presents as an acute lung injury in the vaping population. Vitamin E acetate and its products are implicated as one of the cytotoxic agents causing airway centered pneumonitis. Lipid laden macrophages are found in samples of BAL fluid but their role in cytopathology of the disease remains unclear. We present a 57 years old man who came to the emergency department at Monmouth Medical Center, New Jersey in fall, 2019. Reportedly he has been vaping THC about 100g every day for past three days. At initial presentation, he had fever, shortness of breath and hypoxia requiring supplemental oxygen. He was empirically treated with levofloxacin 500 mg for five days without a significant improvement in his symptoms. Non-contrast chest CT scan showed bilateral ground-glass opacities, indicative of diffuse alveolar damage. He underwent flexible bronchoscopy to rule out infective pneumonia followed by auto-immune work-up that was non-conclusive. He was given 1 mg/kg methylprednisolone with a quick taper of oral steroids leading to the resolution of symptoms. At six months follow-up, imaging showed near resolution of ground-glass opacities. Elsevier 2020-07-25 /pmc/articles/PMC7394920/ /pubmed/32775191 http://dx.doi.org/10.1016/j.rmcr.2020.101174 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Mughal, Mohsin Sheraz Dalmacion, Denise Lauren V. Mirza, Hasan Mahmood Kaur, Ikwinder Preet Dela Cruz, Maria Amanda Kramer, Violet E. E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title | E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title_full | E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title_fullStr | E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title_full_unstemmed | E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title_short | E-cigarette or vaping product use associated lung injury, (EVALI) - A diagnosis of exclusion |
title_sort | e-cigarette or vaping product use associated lung injury, (evali) - a diagnosis of exclusion |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394920/ https://www.ncbi.nlm.nih.gov/pubmed/32775191 http://dx.doi.org/10.1016/j.rmcr.2020.101174 |
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