Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca(2+) in the cytoplasm of C2C12 myoblasts and HCT116 carcinoma cells. We also ob...

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Detalles Bibliográficos
Autores principales: Roy Chowdhury, Anindya, Srinivasan, Satish, Csordás, György, Hajnóczky, György, Avadhani, Narayan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394923/
https://www.ncbi.nlm.nih.gov/pubmed/32738613
http://dx.doi.org/10.1016/j.isci.2020.101370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394923/
https://www.ncbi.nlm.nih.gov/pubmed/32738613
http://dx.doi.org/10.1016/j.isci.2020.101370

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