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Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca(2+) in the cytoplasm of C2C12 myoblasts and HCT116 carcinoma cells. We also ob...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394923/ https://www.ncbi.nlm.nih.gov/pubmed/32738613 http://dx.doi.org/10.1016/j.isci.2020.101370 |