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Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity da...

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Detalles Bibliográficos
Autores principales:	Shi, Miaoying, Bouwmeester, Hans, Rietjens, Ivonne M. C. M., Strikwold, Marije
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395048/ https://www.ncbi.nlm.nih.gov/pubmed/32367273 http://dx.doi.org/10.1007/s00204-020-02766-7

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