Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors

UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) fo...

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Detalles Bibliográficos
Autores principales: Kasteel, E. E. J., Darney, K., Kramer, N. I., Dorne, J. L. C. M., Lautz, L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395075/
https://www.ncbi.nlm.nih.gov/pubmed/32415340
http://dx.doi.org/10.1007/s00204-020-02765-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395075/
https://www.ncbi.nlm.nih.gov/pubmed/32415340
http://dx.doi.org/10.1007/s00204-020-02765-8

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