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Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators

This paper reports a highly sensitive, non-invasive sensor for real-time glucose monitoring from interstitial fluid. The structure is comprised of a chip-less tag sensor which may be taped over the patient’s skin and a reader, that can be embedded in a smartwatch. The tag sensor is energized through...

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Autores principales: Baghelani, Masoud, Abbasi, Zahra, Daneshmand, Mojgan, Light, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395170/
https://www.ncbi.nlm.nih.gov/pubmed/32737348
http://dx.doi.org/10.1038/s41598-020-69547-1
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author Baghelani, Masoud
Abbasi, Zahra
Daneshmand, Mojgan
Light, Peter E.
author_facet Baghelani, Masoud
Abbasi, Zahra
Daneshmand, Mojgan
Light, Peter E.
author_sort Baghelani, Masoud
collection PubMed
description This paper reports a highly sensitive, non-invasive sensor for real-time glucose monitoring from interstitial fluid. The structure is comprised of a chip-less tag sensor which may be taped over the patient’s skin and a reader, that can be embedded in a smartwatch. The tag sensor is energized through the established electromagnetic coupling between the tag and the reader and its frequency response is reflected on the spectrum of the reader in the same manner. The tag sensor consumes zero power as there is no requirement for any active readout or communication circuitry on the tag side. When measuring changes in glucose concentrations within saline replicating interstitial fluid, the sensor was able to detect glucose with an accuracy of ~ 1 mM/l over a physiological range of glucose concentrations with 38 kHz of the resonance frequency shift. This high sensitivity is attained as a result of the proposed new design and extended field concentration on the tag. The impact of some of the possible interferences on the response of the sensor’s performance was also investigated. Variations in electrolyte concentrations within the test samples have a negligible effect on the response of the sensor unless these variations are supra-physiologically large.
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spelling pubmed-73951702020-08-04 Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators Baghelani, Masoud Abbasi, Zahra Daneshmand, Mojgan Light, Peter E. Sci Rep Article This paper reports a highly sensitive, non-invasive sensor for real-time glucose monitoring from interstitial fluid. The structure is comprised of a chip-less tag sensor which may be taped over the patient’s skin and a reader, that can be embedded in a smartwatch. The tag sensor is energized through the established electromagnetic coupling between the tag and the reader and its frequency response is reflected on the spectrum of the reader in the same manner. The tag sensor consumes zero power as there is no requirement for any active readout or communication circuitry on the tag side. When measuring changes in glucose concentrations within saline replicating interstitial fluid, the sensor was able to detect glucose with an accuracy of ~ 1 mM/l over a physiological range of glucose concentrations with 38 kHz of the resonance frequency shift. This high sensitivity is attained as a result of the proposed new design and extended field concentration on the tag. The impact of some of the possible interferences on the response of the sensor’s performance was also investigated. Variations in electrolyte concentrations within the test samples have a negligible effect on the response of the sensor unless these variations are supra-physiologically large. Nature Publishing Group UK 2020-07-31 /pmc/articles/PMC7395170/ /pubmed/32737348 http://dx.doi.org/10.1038/s41598-020-69547-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Baghelani, Masoud
Abbasi, Zahra
Daneshmand, Mojgan
Light, Peter E.
Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title_full Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title_fullStr Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title_full_unstemmed Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title_short Non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
title_sort non-invasive continuous-time glucose monitoring system using a chipless printable sensor based on split ring microwave resonators
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395170/
https://www.ncbi.nlm.nih.gov/pubmed/32737348
http://dx.doi.org/10.1038/s41598-020-69547-1
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