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Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications
Integrating a light source inside a Lab-on-a-Chip (LOC) platform has always been as challenging as much as an appealing task. Besides the manufacturing issues, one of the most limiting aspects is due to the need for an energy source to feed the light emission. A solution independent of external ener...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395173/ https://www.ncbi.nlm.nih.gov/pubmed/32737346 http://dx.doi.org/10.1038/s41598-020-69581-z |
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author | Storti, Filippo Bonfadini, Silvio Criante, Luigino |
author_facet | Storti, Filippo Bonfadini, Silvio Criante, Luigino |
author_sort | Storti, Filippo |
collection | PubMed |
description | Integrating a light source inside a Lab-on-a-Chip (LOC) platform has always been as challenging as much as an appealing task. Besides the manufacturing issues, one of the most limiting aspects is due to the need for an energy source to feed the light emission. A solution independent of external energy sources can be given by Chemiluminescence (CL): a well-known chemical phenomenon in which light emission is achieved because of a chemical reaction. Here we present the fabrication and the characterization of a chemiluminescent light source, fully integrated on a microfluidic platform by means of the direct writing technique known as Femtosecond Laser Micromachining. The key advantage is the possibility to insert within LOC devices light sources with complete placement freedom in 3D, wide flexibility of the emitting source geometry and no external feeding energy. The characterization is carried out by investigating the effect of confining a chemiluminescent rubrene-based reaction in small volumes and the inject pressures impact on the emission spectra. Moreover, exploiting microfluidics principles, it’s possible to move from the typical flash-type CL emission to a prolonged one (several hours). This allows to disengage bulky, external light sources, adding an extra step on the road to real device portability. |
format | Online Article Text |
id | pubmed-7395173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73951732020-08-04 Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications Storti, Filippo Bonfadini, Silvio Criante, Luigino Sci Rep Article Integrating a light source inside a Lab-on-a-Chip (LOC) platform has always been as challenging as much as an appealing task. Besides the manufacturing issues, one of the most limiting aspects is due to the need for an energy source to feed the light emission. A solution independent of external energy sources can be given by Chemiluminescence (CL): a well-known chemical phenomenon in which light emission is achieved because of a chemical reaction. Here we present the fabrication and the characterization of a chemiluminescent light source, fully integrated on a microfluidic platform by means of the direct writing technique known as Femtosecond Laser Micromachining. The key advantage is the possibility to insert within LOC devices light sources with complete placement freedom in 3D, wide flexibility of the emitting source geometry and no external feeding energy. The characterization is carried out by investigating the effect of confining a chemiluminescent rubrene-based reaction in small volumes and the inject pressures impact on the emission spectra. Moreover, exploiting microfluidics principles, it’s possible to move from the typical flash-type CL emission to a prolonged one (several hours). This allows to disengage bulky, external light sources, adding an extra step on the road to real device portability. Nature Publishing Group UK 2020-07-31 /pmc/articles/PMC7395173/ /pubmed/32737346 http://dx.doi.org/10.1038/s41598-020-69581-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Storti, Filippo Bonfadini, Silvio Criante, Luigino Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title | Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title_full | Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title_fullStr | Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title_full_unstemmed | Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title_short | Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
title_sort | battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395173/ https://www.ncbi.nlm.nih.gov/pubmed/32737346 http://dx.doi.org/10.1038/s41598-020-69581-z |
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