Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the degeneration of upper and lower motor neurons (MNs). We find a significant reduction of the retromer complex subunit VPS35 in iPSCs-derived MNs from ALS patients, in MNs from ALS post mortem explants and in MNs from SOD1G93A...

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Detalles Bibliográficos
Autores principales: Muzio, Luca, Sirtori, Riccardo, Gornati, Davide, Eleuteri, Simona, Fossaghi, Andrea, Brancaccio, Diego, Manzoni, Leonardo, Ottoboni, Linda, Feo, Luca De, Quattrini, Angelo, Mastrangelo, Eloise, Sorrentino, Luca, Scalone, Emanuele, Comi, Giancarlo, Marinelli, Luciana, Riva, Nilo, Milani, Mario, Seneci, Pierfausto, Martino, Gianvito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395176/
https://www.ncbi.nlm.nih.gov/pubmed/32737286
http://dx.doi.org/10.1038/s41467-020-17524-7

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