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Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues
Opioids, amphetamines, and other types of substances have been widely abused around the world. Opioid dependence and tolerance are two distinct phenomena that have been associated with substance abuse issues. The management of its adverse consequences is becoming more challenging. More and more peop...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mashhad University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395189/ https://www.ncbi.nlm.nih.gov/pubmed/32774804 http://dx.doi.org/10.22038/ijbms.2020.41678.9841 |
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author | Mohd Adnan, Liyana Hazwani Abu Bakar, Nor Hidayah Simbak, Nordin Mohamad, Nasir Ismail, Rusli Ahmad, Nor Zidah Mustafa, Nor Suliana Md Fauzi, Nurul Farah Aina |
author_facet | Mohd Adnan, Liyana Hazwani Abu Bakar, Nor Hidayah Simbak, Nordin Mohamad, Nasir Ismail, Rusli Ahmad, Nor Zidah Mustafa, Nor Suliana Md Fauzi, Nurul Farah Aina |
author_sort | Mohd Adnan, Liyana Hazwani |
collection | PubMed |
description | Opioids, amphetamines, and other types of substances have been widely abused around the world. Opioid dependence and tolerance are two distinct phenomena that have been associated with substance abuse issues. The management of its adverse consequences is becoming more challenging. More and more people are treated in Methadone Maintenance Therapy (MMT) program yet the issues are still unresolved. Researchers are continuing to study the best formulation in treating opioid dependent people starting with modern and alternative drug therapies. Since 2008 , thymoquinone (TQ) has been extensively studied by researchers around the world and has emerged to be a new potential drug candidate in managing substance abuse issues. Thus, the aim of this article is to review the effects that TQ may have on opioid dependent subjects and other abused substances such as amphetamine may have been studied. All of the articles from 2008 until 2019 involving the effects of TQ on substance abuse from Google Scholar®, Scopus®, and Pubmed® databases have been searched and reviewed. The keywords used were thymoquinone, opioid dependence, amphetamine, and Nigella sativa. The research results also have been discussed in this article. Based on the research conducted, TQ was effective in reducing the adverse health consequences associated with substance abuse such as withdrawal symptoms, tolerance, and cell damages. It is concluded that TQ could be a potential drug that can be complemented with the currently available drugs in substance abuse therapies. |
format | Online Article Text |
id | pubmed-7395189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-73951892020-08-07 Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues Mohd Adnan, Liyana Hazwani Abu Bakar, Nor Hidayah Simbak, Nordin Mohamad, Nasir Ismail, Rusli Ahmad, Nor Zidah Mustafa, Nor Suliana Md Fauzi, Nurul Farah Aina Iran J Basic Med Sci Mini Review Opioids, amphetamines, and other types of substances have been widely abused around the world. Opioid dependence and tolerance are two distinct phenomena that have been associated with substance abuse issues. The management of its adverse consequences is becoming more challenging. More and more people are treated in Methadone Maintenance Therapy (MMT) program yet the issues are still unresolved. Researchers are continuing to study the best formulation in treating opioid dependent people starting with modern and alternative drug therapies. Since 2008 , thymoquinone (TQ) has been extensively studied by researchers around the world and has emerged to be a new potential drug candidate in managing substance abuse issues. Thus, the aim of this article is to review the effects that TQ may have on opioid dependent subjects and other abused substances such as amphetamine may have been studied. All of the articles from 2008 until 2019 involving the effects of TQ on substance abuse from Google Scholar®, Scopus®, and Pubmed® databases have been searched and reviewed. The keywords used were thymoquinone, opioid dependence, amphetamine, and Nigella sativa. The research results also have been discussed in this article. Based on the research conducted, TQ was effective in reducing the adverse health consequences associated with substance abuse such as withdrawal symptoms, tolerance, and cell damages. It is concluded that TQ could be a potential drug that can be complemented with the currently available drugs in substance abuse therapies. Mashhad University of Medical Sciences 2020-07 /pmc/articles/PMC7395189/ /pubmed/32774804 http://dx.doi.org/10.22038/ijbms.2020.41678.9841 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Mini Review Mohd Adnan, Liyana Hazwani Abu Bakar, Nor Hidayah Simbak, Nordin Mohamad, Nasir Ismail, Rusli Ahmad, Nor Zidah Mustafa, Nor Suliana Md Fauzi, Nurul Farah Aina Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title | Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title_full | Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title_fullStr | Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title_full_unstemmed | Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title_short | Thymoquinone: From Nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
title_sort | thymoquinone: from nigella sativa to a protective pharmacological compound in managing opioid dependence and amphetamine type stimulant issues |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395189/ https://www.ncbi.nlm.nih.gov/pubmed/32774804 http://dx.doi.org/10.22038/ijbms.2020.41678.9841 |
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