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A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395212/ https://www.ncbi.nlm.nih.gov/pubmed/32740860 http://dx.doi.org/10.1007/s12016-020-08804-7 |
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author | Mutua, Victoria Gershwin, Laurel J. |
author_facet | Mutua, Victoria Gershwin, Laurel J. |
author_sort | Mutua, Victoria |
collection | PubMed |
description | Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients. |
format | Online Article Text |
id | pubmed-7395212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-73952122020-08-03 A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics Mutua, Victoria Gershwin, Laurel J. Clin Rev Allergy Immunol Article Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients. Springer US 2020-08-01 2021 /pmc/articles/PMC7395212/ /pubmed/32740860 http://dx.doi.org/10.1007/s12016-020-08804-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mutua, Victoria Gershwin, Laurel J. A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title | A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title_full | A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title_fullStr | A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title_full_unstemmed | A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title_short | A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics |
title_sort | review of neutrophil extracellular traps (nets) in disease: potential anti-nets therapeutics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395212/ https://www.ncbi.nlm.nih.gov/pubmed/32740860 http://dx.doi.org/10.1007/s12016-020-08804-7 |
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