Cargando…

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial...

Descripción completa

Detalles Bibliográficos
Autores principales: Mutua, Victoria, Gershwin, Laurel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395212/
https://www.ncbi.nlm.nih.gov/pubmed/32740860
http://dx.doi.org/10.1007/s12016-020-08804-7
_version_ 1783565366595682304
author Mutua, Victoria
Gershwin, Laurel J.
author_facet Mutua, Victoria
Gershwin, Laurel J.
author_sort Mutua, Victoria
collection PubMed
description Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients.
format Online
Article
Text
id pubmed-7395212
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-73952122020-08-03 A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics Mutua, Victoria Gershwin, Laurel J. Clin Rev Allergy Immunol Article Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients. Springer US 2020-08-01 2021 /pmc/articles/PMC7395212/ /pubmed/32740860 http://dx.doi.org/10.1007/s12016-020-08804-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Mutua, Victoria
Gershwin, Laurel J.
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title_full A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title_fullStr A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title_full_unstemmed A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title_short A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
title_sort review of neutrophil extracellular traps (nets) in disease: potential anti-nets therapeutics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395212/
https://www.ncbi.nlm.nih.gov/pubmed/32740860
http://dx.doi.org/10.1007/s12016-020-08804-7
work_keys_str_mv AT mutuavictoria areviewofneutrophilextracellulartrapsnetsindiseasepotentialantinetstherapeutics
AT gershwinlaurelj areviewofneutrophilextracellulartrapsnetsindiseasepotentialantinetstherapeutics
AT mutuavictoria reviewofneutrophilextracellulartrapsnetsindiseasepotentialantinetstherapeutics
AT gershwinlaurelj reviewofneutrophilextracellulartrapsnetsindiseasepotentialantinetstherapeutics