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FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

BACKGROUND: Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expressed on the surface of lymphatic endothel...

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Detalles Bibliográficos
Autores principales:	Shrestha, Shikshya, Cho, Woohyun, Stump, Benjamin, Imani, Jewel, Lamattina, Anthony M., Louis, Pierce H., Pazzanese, James, Rosas, Ivan O., Visner, Gary, Perrella, Mark A., El-Chemaly, Souheil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395348/ https://www.ncbi.nlm.nih.gov/pubmed/32736525 http://dx.doi.org/10.1186/s10020-020-00204-z

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