TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

Mast cells and basophils are main drivers of allergic reactions and anaphylaxis, for which prevalence is rapidly increasing. Activation of these cells leads to a tightly controlled release of inflammatory mediators stored in secretory granules. The release of these granules is dependent on intracell...

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Detalles Bibliográficos
Autores principales: Arlt, Elisabeth, Fraticelli, Marco, Tsvilovskyy, Volodymyr, Nadolni, Wiebke, Breit, Andreas, O’Neill, Thomas J., Resenberger, Stefanie, Wennemuth, Gunther, Wahl-Schott, Christian, Biel, Martin, Grimm, Christian, Freichel, Marc, Gudermann, Thomas, Klugbauer, Norbert, Boekhoff, Ingrid, Zierler, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395440/
https://www.ncbi.nlm.nih.gov/pubmed/32661165
http://dx.doi.org/10.1073/pnas.1920122117

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