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Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti–HIV-1 IgG1 antibodies in vivo

In combating viral infections, the Fab portion of an antibody could mediate virus neutralization, whereas Fc engagement of Fc-γ receptors (FcγRs) could mediate an array of effector functions. Evidence abounds that effector functions are important in controlling infections by influenza, Ebola, or HIV...

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Detalles Bibliográficos
Autores principales:	Wang, Pengfei, Gajjar, Mili R., Yu, Jian, Padte, Neal N., Gettie, Agegnehu, Blanchard, James L., Russell-Lodrigue, Kasi, Liao, Laura E., Perelson, Alan S., Huang, Yaoxing, Ho, David D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395461/ https://www.ncbi.nlm.nih.gov/pubmed/32665438 http://dx.doi.org/10.1073/pnas.2008190117

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