Cargando…
Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination
CCN3 is a matricellular protein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex vivo. CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelination, and we sought to investigate the expression and role of CCN3 du...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395501/ https://www.ncbi.nlm.nih.gov/pubmed/32651278 http://dx.doi.org/10.1073/pnas.1922089117 |
_version_ | 1783565413385240576 |
---|---|
author | de la Vega Gallardo, Nira Penalva, Rosana Dittmer, Marie Naughton, Michelle Falconer, John Moffat, Jill de la Fuente, Alerie G. Hombrebueno, José R. Lin, Zhiyong Perbal, Bernard Ingram, Rebecca J. Evergren, Emma Fitzgerald, Denise C. |
author_facet | de la Vega Gallardo, Nira Penalva, Rosana Dittmer, Marie Naughton, Michelle Falconer, John Moffat, Jill de la Fuente, Alerie G. Hombrebueno, José R. Lin, Zhiyong Perbal, Bernard Ingram, Rebecca J. Evergren, Emma Fitzgerald, Denise C. |
author_sort | de la Vega Gallardo, Nira |
collection | PubMed |
description | CCN3 is a matricellular protein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex vivo. CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelination, and we sought to investigate the expression and role of CCN3 during these processes. We found CCN3 to be expressed predominantly by neurons in distinct areas of the CNS, primarily the cerebral cortex, hippocampus, amygdala, suprachiasmatic nuclei, anterior olfactory nuclei, and spinal cord gray matter. CCN3 was transiently up-regulated following demyelination in the brain of cuprizone-fed mice and spinal cord lesions of mice injected with lysolecithin. However, CCN3(−/−) mice did not exhibit significantly different numbers of oligodendroglia or differentiated oligodendrocytes in the healthy or remyelinating CNS, compared to WT controls. These results suggest that despite robust and dynamic expression in the CNS, CCN3 is not required for efficient myelination or remyelination in the murine CNS in vivo. |
format | Online Article Text |
id | pubmed-7395501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-73955012020-08-07 Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination de la Vega Gallardo, Nira Penalva, Rosana Dittmer, Marie Naughton, Michelle Falconer, John Moffat, Jill de la Fuente, Alerie G. Hombrebueno, José R. Lin, Zhiyong Perbal, Bernard Ingram, Rebecca J. Evergren, Emma Fitzgerald, Denise C. Proc Natl Acad Sci U S A Biological Sciences CCN3 is a matricellular protein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex vivo. CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelination, and we sought to investigate the expression and role of CCN3 during these processes. We found CCN3 to be expressed predominantly by neurons in distinct areas of the CNS, primarily the cerebral cortex, hippocampus, amygdala, suprachiasmatic nuclei, anterior olfactory nuclei, and spinal cord gray matter. CCN3 was transiently up-regulated following demyelination in the brain of cuprizone-fed mice and spinal cord lesions of mice injected with lysolecithin. However, CCN3(−/−) mice did not exhibit significantly different numbers of oligodendroglia or differentiated oligodendrocytes in the healthy or remyelinating CNS, compared to WT controls. These results suggest that despite robust and dynamic expression in the CNS, CCN3 is not required for efficient myelination or remyelination in the murine CNS in vivo. National Academy of Sciences 2020-07-28 2020-07-10 /pmc/articles/PMC7395501/ /pubmed/32651278 http://dx.doi.org/10.1073/pnas.1922089117 Text en Copyright © 2020 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences de la Vega Gallardo, Nira Penalva, Rosana Dittmer, Marie Naughton, Michelle Falconer, John Moffat, Jill de la Fuente, Alerie G. Hombrebueno, José R. Lin, Zhiyong Perbal, Bernard Ingram, Rebecca J. Evergren, Emma Fitzgerald, Denise C. Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title | Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title_full | Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title_fullStr | Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title_full_unstemmed | Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title_short | Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination |
title_sort | dynamic ccn3 expression in the murine cns does not confer essential roles in myelination or remyelination |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395501/ https://www.ncbi.nlm.nih.gov/pubmed/32651278 http://dx.doi.org/10.1073/pnas.1922089117 |
work_keys_str_mv | AT delavegagallardonira dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT penalvarosana dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT dittmermarie dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT naughtonmichelle dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT falconerjohn dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT moffatjill dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT delafuentealerieg dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT hombrebuenojoser dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT linzhiyong dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT perbalbernard dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT ingramrebeccaj dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT evergrenemma dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination AT fitzgeralddenisec dynamicccn3expressioninthemurinecnsdoesnotconferessentialrolesinmyelinationorremyelination |