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Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery

BACKGROUND: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. CASE DE...

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Autores principales: Sánchez-Ortega, Juan Francisco, Aguas-Valiente, Jesús, Sota-Ochoa, Patricia, Calatayud-Pérez, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395537/
https://www.ncbi.nlm.nih.gov/pubmed/32754353
http://dx.doi.org/10.25259/SNI_272_2020
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author Sánchez-Ortega, Juan Francisco
Aguas-Valiente, Jesús
Sota-Ochoa, Patricia
Calatayud-Pérez, Juan
author_facet Sánchez-Ortega, Juan Francisco
Aguas-Valiente, Jesús
Sota-Ochoa, Patricia
Calatayud-Pérez, Juan
author_sort Sánchez-Ortega, Juan Francisco
collection PubMed
description BACKGROUND: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. CASE DESCRIPTION: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC. CONCLUSION: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.
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spelling pubmed-73955372020-08-03 Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery Sánchez-Ortega, Juan Francisco Aguas-Valiente, Jesús Sota-Ochoa, Patricia Calatayud-Pérez, Juan Surg Neurol Int Case Report BACKGROUND: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. CASE DESCRIPTION: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC. CONCLUSION: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope. Scientific Scholar 2020-07-04 /pmc/articles/PMC7395537/ /pubmed/32754353 http://dx.doi.org/10.25259/SNI_272_2020 Text en Copyright: © 2020 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sánchez-Ortega, Juan Francisco
Aguas-Valiente, Jesús
Sota-Ochoa, Patricia
Calatayud-Pérez, Juan
Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title_full Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title_fullStr Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title_full_unstemmed Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title_short Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery
title_sort glioblastoma with primitive neuronal component: a case report and considerations of fluorescence-guided surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395537/
https://www.ncbi.nlm.nih.gov/pubmed/32754353
http://dx.doi.org/10.25259/SNI_272_2020
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