Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis

BACKGROUND: Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy...

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Detalles Bibliográficos
Autores principales: Nishiyama, Kei, Watanabe, Yuka, Ishimura, Masataka, Tetsuhara, Kenichi, Imai, Takashi, Kanemasa, Hikaru, Ueki, Kenji, Motomura, Yoshitomo, Kaku, Noriyuki, Sakai, Yasunari, Imadome, Ken-Ichi, Ohga, Shouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395673/
https://www.ncbi.nlm.nih.gov/pubmed/32760751
http://dx.doi.org/10.1093/ofid/ofaa288
Descripción
Sumario:BACKGROUND: Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. METHODS: Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. RESULTS: A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. CONCLUSIONS: Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.

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