Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target

In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin αVβ3 plays an important role in this process. In prostate cancer, αVβ3 mediates adhesion, invasion, immune escape...

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Detalles Bibliográficos
Autores principales: Tang, Lin, Xu, Meng, Zhang, Long, Qu, Lin, Liu, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395689/
https://www.ncbi.nlm.nih.gov/pubmed/32801764
http://dx.doi.org/10.2147/OTT.S258252
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author Tang, Lin
Xu, Meng
Zhang, Long
Qu, Lin
Liu, Xiaoyan
author_facet Tang, Lin
Xu, Meng
Zhang, Long
Qu, Lin
Liu, Xiaoyan
author_sort Tang, Lin
collection PubMed
description In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin αVβ3 plays an important role in this process. In prostate cancer, αVβ3 mediates adhesion, invasion, immune escape and neovascularization through interactions with different ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD structure could also bind to αVβ3 and cause a number of biological effects. In this article, we summarized the ligand and downstream proteins related to αVβ3-mediated prostate cancer metastasis as well as some diagnostic and therapeutic measures targeting αVβ3.
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spelling pubmed-73956892020-08-13 Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target Tang, Lin Xu, Meng Zhang, Long Qu, Lin Liu, Xiaoyan Onco Targets Ther Review In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin αVβ3 plays an important role in this process. In prostate cancer, αVβ3 mediates adhesion, invasion, immune escape and neovascularization through interactions with different ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD structure could also bind to αVβ3 and cause a number of biological effects. In this article, we summarized the ligand and downstream proteins related to αVβ3-mediated prostate cancer metastasis as well as some diagnostic and therapeutic measures targeting αVβ3. Dove 2020-07-28 /pmc/articles/PMC7395689/ /pubmed/32801764 http://dx.doi.org/10.2147/OTT.S258252 Text en © 2020 Tang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tang, Lin
Xu, Meng
Zhang, Long
Qu, Lin
Liu, Xiaoyan
Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title_full Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title_fullStr Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title_full_unstemmed Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title_short Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
title_sort role of αvβ3 in prostate cancer: metastasis initiator and important therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395689/
https://www.ncbi.nlm.nih.gov/pubmed/32801764
http://dx.doi.org/10.2147/OTT.S258252
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